GAtherton, Author at Aspergillosis Patients & Carers Support

Patient talking with a healthcare professional about support and treatment choices

Complementary therapies and aspergillosis: finding relief without losing sight of treatment

Living with aspergillosis or another long-term health condition can be exhausting. Even when treatment is helping, people may still have breathlessness, fatigue, pain, poor sleep, anxiety, stomach problems or difficult medicine side effects.

It is understandable to look for something more: relief, hope, control, time to talk, or a way to feel like life is not entirely organised around illness. This can lead people to explore complementary therapies such as hypnotherapy, acupuncture or homeopathy.

You should not be judged for that. You deserve honest information about what may help, what is uncertain, and what must not replace essential medical care.

Two things can be true at once

A complementary therapy may make someone feel better. They may sleep better, feel calmer, have less pain, cope better with symptoms or feel more hopeful.

That does not necessarily mean it has treated the underlying disease.

The helpful ingredient may not be the advertised treatment. Time, attention, reassurance, relaxation, expectation, a clear plan and feeling listened to can all make a genuine difference to how illness is experienced. These benefits are real, but they are different from clearing a fungal infection, controlling ABPA inflammation or reversing lung damage.

Why people seek complementary therapies

People do not usually seek these therapies because they do not care about their health or reject conventional medicine. Common reasons include:

ongoing symptoms despite appropriate treatment;
side effects or the burden of taking several medicines;
fear, anxiety, poor sleep or loss of confidence;
feeling that appointments leave too little time to discuss day-to-day coping;
wanting to regain some control when illness feels unpredictable;
recommendations from friends, family or online communities.

Aspergillosis is uncommon and symptoms can fluctuate. It can be especially hard when people feel that others do not fully understand what they are living with.

Hypnotherapy: a skill for reducing the extra burden of illness

Despite its name, responsible clinical hypnotherapy is not stage hypnosis or loss of control. It is a guided, deeply focused relaxation technique using imagery and suggestions to practise a calmer response to symptoms.

It may help some people with anxiety, panic, sleep difficulties, pain, nausea or the fear–symptom cycle. For example:

breathlessness or pain → “this is dangerous” → anxiety and physical alarm → more tension, faster breathing and worse symptoms.

Hypnotherapy, paced breathing, mindfulness and CBT-style skills can help interrupt this cycle. They do not suggest that symptoms are imaginary. They aim to prevent fear and physical alarm from adding an avoidable second layer of distress to a real illness.

Hypnotherapy does not treat fungal infection, ABPA, asthma inflammation or structural lung disease. It may be a supportive tool alongside appropriate medical care.

NICE recognises hypnotherapy as a possible psychological intervention for some people with difficult irritable bowel syndrome, but it is not a general treatment for aspergillosis or chronic illness.

Acupuncture: possible symptom relief, but not a treatment for aspergillosis

Acupuncture combines a physical procedure with attention, expectation, relaxation and a therapeutic ritual. Some people report that it helps them feel calmer or gives relief from pain, nausea or general discomfort.

The needles are a real physical stimulus, but research suggests that much of the overall benefit can also come from the wider therapeutic encounter: time with a practitioner, expectation of benefit and a sense that something positive is being done.

NICE says that a single course of acupuncture or dry needling can be considered for adults with chronic primary pain. This is not a general recommendation for every painful condition, and it is not a treatment for aspergillosis, fungal infection, ABPA or lung damage.

For some selected pain conditions, needling may add a small short-term benefit beyond a sham procedure. It should be presented honestly as possible symptom support, not as a cure.

Homeopathy: feeling supported is not the same as treating disease

Homeopathic consultations can be long and personal. People may feel heard, reassured and hopeful, and may value having an explanation and a plan. Those experiences can help someone feel better.

However, there is no good-quality evidence that homeopathy treats heart disease, fungal infection, aspergillosis, asthma, ABPA or other medical conditions. Homeopathic remedies are often diluted so extremely that little or none of the original ingredient is likely to remain.

NICE does not recommend homeopathy as treatment for medical conditions. It must never be used instead of prescribed treatment, monitoring, investigations or urgent medical assessment.

When medicine itself is difficult to live with

Medicines can cause major side effects. People may experience nausea, diarrhoea, sleep disturbance, dizziness, fatigue, mood changes, interactions, or simply feel overwhelmed by the number of tablets and treatments they need.

If you have stopped, reduced, or are thinking of stopping a medicine because it makes you feel unwell, please tell your GP, specialist or pharmacist. You will not be judged. There may be a safer alternative, a dose adjustment, a different formulation, a change in timing, or other ways to reduce the treatment burden.

For people taking antifungal medicines, drug-level monitoring can sometimes help clinicians find a dose that is both effective and more tolerable. Do not make dose changes on your own.

Antibiotics can also affect the gut and may cause troublesome side effects. This is one reason why they should be used carefully and for clear reasons. But concerns about side effects or the gut microbiome should not lead someone to leave an important infection untreated.

How to assess a new therapy safely

Be clear about the aim. Is it intended to help sleep, anxiety, pain, nausea or coping? That is different from a claim to clear fungus, repair lungs or “boost immunity”.
Ask what else changed. Symptoms naturally fluctuate. Improvement may also follow a medicine change, more rest, a supportive conversation or a change in routine.
Keep essential treatment and monitoring in place. A complementary therapy should not demand that you stop prescribed treatment.
Set a realistic goal. For example, fewer panic episodes, improved sleep or being able to go for a short walk with more confidence.
Check supplements and herbal remedies first. “Natural” does not always mean safe, especially alongside azole antifungals or other complex medicines.
Stop if it is causing harm. This includes physical side effects, unreasonable cost, pressure to reject medical advice, or promises that sound too good to be true.

Evidence-based support for anxiety and panic

When anxiety, panic, sleep problems or fear of symptoms are having a major impact, it can help to ask about support designed specifically for those problems. This might include:

CBT or other structured talking therapies;
applied relaxation, paced breathing or pulmonary rehabilitation/physiotherapy where appropriate;
mindfulness-based approaches;
support for sleep, pacing and day-to-day symptom management;
medication for anxiety or panic when appropriate, discussed and reviewed with a clinician.

Access to psychological support can be limited and waiting times can be long. While waiting, ask your GP or specialist what safe self-management, local talking-therapy services or other support may be available.

When to seek help urgently

Do not stop or change prescribed medicines on the basis of this page or a complementary-therapy claim.

Seek urgent medical help for new or worsening chest pain, severe breathlessness, fainting, signs of a serious allergic reaction, or any sudden severe deterioration.

The important message

There may not always be a simple cure or a way to remove every symptom. But there can still be ways to reduce distress, improve function, protect independence and make life feel larger than illness.

It is reasonable to seek support. The safest approach is to retain what genuinely helps you cope, be honest with your clinical team about what you are trying, and keep evidence-based treatment and monitoring in place.

You are not ignoring your illness when you learn to calm the alarm around it.

Further information

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by GAtherton

Person checking blood glucose at home while managing diabetes and aspergillosis

Diabetes and aspergillosis: understanding the connection.

Diabetes is common, and many people living with aspergillosis also have type 1 diabetes, type 2 diabetes or raised blood glucose caused by steroid treatment.

Having diabetes does not mean that you will develop aspergillosis, and most people with diabetes never do. However, diabetes can be one of several factors that affect how the body responds to infection and how treatment is managed. It is particularly relevant when it occurs alongside lung damage, poor nutrition, long-term steroid treatment or a serious illness.

Why can diabetes matter?

When blood glucose levels are frequently above their usual target range, the body may not fight infections as effectively. High glucose can affect the function of some immune cells and may make recovery from infection more difficult.

For aspergillosis, diabetes is usually one part of the picture, rather than the sole explanation. Other important factors may include:

previous tuberculosis or another lung infection that has left cavities or scarring;
bronchiectasis, COPD, sarcoidosis or another long-term lung condition;
long-term or repeated corticosteroid treatment;
low body weight, poor appetite or malnutrition;
serious viral illness, hospital admission or intensive care treatment; and
medicines or conditions that suppress the immune system.

In other words, risk can “stack up”. Diabetes may add to the effect of existing lung disease or treatment, but it does not make aspergillosis inevitable.

Does high blood sugar “feed” Aspergillus?

Not in the simple sense that sugar in the bloodstream directly feeds fungus in the lungs. Blood glucose and the airways are separated by several protective barriers.

There is a small amount of glucose in the thin fluid lining the airways, and persistently high blood glucose can alter that environment. However, the strongest evidence that this directly encourages growth is for some bacteria, not for Aspergillus specifically.

The more important reason that glucose control matters is the immune system. Persistently high blood glucose can affect how immune cells recognise, reach and destroy germs, including fungi. It may therefore make infections harder to control or recovery slower.

The practical message is not to blame yourself for a high reading or to try to manage an infection through diet alone. Keeping glucose within the range agreed with your diabetes team supports your immune system and recovery, alongside the right respiratory and antifungal treatment.

Diabetes and chronic pulmonary aspergillosis

Chronic pulmonary aspergillosis (CPA) usually develops in lungs that have already been damaged. Diabetes is recognised as one factor that may increase vulnerability, especially in people with previous tuberculosis, weight loss or poor nutritional status.

A recent study in people being treated for pulmonary tuberculosis found that diabetes and low body weight were both associated with a higher likelihood of CPA. This is useful evidence, but it does not mean that every person with diabetes requires tests for aspergillosis. Testing is guided by the whole clinical picture: symptoms, previous lung disease, scans, blood tests and sputum results.

Speak to a healthcare professional if you have diabetes and develop persistent or worsening respiratory symptoms, particularly if you also have a history of significant lung disease.

Steroids: an important practical issue

Corticosteroids are an important treatment for many people with asthma and ABPA. They can reduce harmful inflammation and, in some situations, are essential. However, steroid tablets and injections can raise blood glucose levels. They may make existing diabetes harder to manage or occasionally trigger steroid-induced diabetes.

This does not mean that you should avoid, reduce or stop steroids on your own. Suddenly stopping steroid treatment can be dangerous. Instead, make sure the clinician prescribing steroids knows that you have diabetes or have previously had high blood glucose.

Your diabetes team, GP or specialist team may recommend temporary changes to glucose monitoring or diabetes medication while you are taking steroids. The right plan is individual and may change when the steroid dose is reduced.

What about inhaled steroids?

Inhaled corticosteroids generally have less effect on blood glucose than high-dose steroid tablets or injections, but some people may still notice a change, particularly at higher doses. Continue your inhalers as prescribed and discuss concerns with your usual healthcare team rather than stopping treatment.

Looking after both conditions

Good diabetes care supports your overall health while you are being treated for aspergillosis. Useful steps include:

attending diabetes reviews and monitoring blood glucose as your team has advised;
telling your diabetes team about new steroid treatment, significant infection or a hospital admission;
telling your aspergillosis or respiratory team about diabetes medicines and any major changes to them;
keeping regular meals and fluids going as far as possible when you are unwell;
asking for dietary support if poor appetite, weight loss or nausea are making it difficult to eat enough; and
keeping vaccinations up to date where they are recommended for you.

Antifungal medicines can interact with many other treatments. Bring an up-to-date list of all medicines, including diabetes medicines, to appointments and ask a pharmacist or prescriber to check for interactions whenever something changes.

When you are unwell

Infections can raise blood glucose levels, even if you are eating less than usual. If you have diabetes, follow the sick-day guidance given by your diabetes team. This may include checking glucose more often and, for some people, checking ketones.

Contact your diabetes team, GP, NHS 111 or your usual urgent-care route if you are unable to keep fluids down, have repeatedly high or low readings outside the range your team has advised, have ketones, or are becoming increasingly unwell.

If you have symptoms that might suggest worsening lung disease — such as a persistent increase in cough, breathlessness, fever, weight loss, new chest pain or coughing up blood — contact the team managing your respiratory condition. Significant coughing up of blood requires urgent medical assessment.

Key messages

Diabetes is common and most people with diabetes do not develop aspergillosis.
It can contribute to risk when combined with lung damage, poor nutrition, steroid treatment or severe illness.
High blood glucose does not simply “feed” Aspergillus in the lungs; its more important effect is on immune function and recovery.
Steroids can raise blood glucose, so diabetes management may need temporary adjustment during treatment for ABPA or another condition.
Do not stop steroids, antifungals or diabetes medicines without medical advice.
Good communication between your diabetes, respiratory and pharmacy teams helps keep treatment safe.

Further information

This information is for general guidance and does not replace advice from the healthcare professionals managing your diabetes or aspergillosis.

by GAtherton

Patient receiving a specialist antifungal medicine delivery at home

Getting specialist antifungal medicines delivered to your home: a guide to NHS homecare

Finding a regular supply of an antifungal medicine such as itraconazole can sometimes be difficult. A local pharmacy may not have the right strength, brand or formulation available immediately, or may need to order it from a wholesaler. This can be worrying when the medicine is part of your long-term treatment for aspergillosis.

One option that may be available for some patients is an NHS medicines homecare service. This article explains what that means, who may be eligible, and what to do if your supply is running low.

What is a medicines homecare service?

Medicines homecare is a way of supplying certain hospital-prescribed medicines directly to your home, workplace or another suitable UK address. Your hospital clinical team writes the prescription and the hospital pharmacy sends it to an approved external homecare provider. The provider dispenses the medicine and arranges delivery.

Some homecare services also provide nursing support, equipment or training for medicines that need to be injected or administered at home. For oral antifungals, the service is usually about safe dispensing and reliable delivery.

Homecare companies are commercial providers working under NHS contracts; they are not replacements for your consultant, specialist nurse, GP or hospital pharmacist. Your hospital team remains responsible for the clinical decisions about your treatment.

Could this be available for itraconazole?

Possibly. It depends on the medicine, your individual treatment plan, and the arrangements at the hospital that prescribes it. Homecare is more commonly used for specialist, high-cost or hospital-only medicines, but some long-term oral treatments may also be suitable.

If you are repeatedly struggling to obtain itraconazole through the usual route, it is reasonable to ask your specialist team or hospital pharmacy:

Whether your itraconazole can be supplied through the Trust’s medicines homecare service.
Whether a different dispensing route is available while supply is difficult.
How much buffer stock you should aim to have at home.
Who to contact if a delivery or prescription is delayed.

The provider is chosen by the NHS Trust and may vary between hospitals and medicines. Sciensus is one example of a company that provides NHS medicines homecare, but it is not the only provider and patients cannot normally self-refer directly to a particular company.

What homecare can help with — and what it cannot

Homecare can save repeated journeys to hospital and may give you a more predictable delivery arrangement. The service should contact you to arrange deliveries, and you or an agreed representative will normally need to be available to receive and sign for them.

However, homecare cannot create stock where there is a wider manufacturing or national supply problem. Medicine shortages can arise for several reasons, including manufacturing difficulties, shortages of raw materials, increased demand, distribution problems or regulatory issues.

Where there is a shortage, your hospital pharmacy and specialist team may need to find available stock, arrange an alternative formulation, or advise on a different treatment. Do not make these changes yourself.

Itraconazole: do not assume that all forms are interchangeable

Itraconazole is available in different formulations, including capsules and oral liquid. They are absorbed differently and should not be swapped without advice from the clinician or pharmacist managing your treatment.

In particular, itraconazole oral solution has higher bioavailability than capsules. The timing of doses in relation to food can also differ between formulations. Any change may require a dose adjustment and, for many people being treated for aspergillosis, repeat therapeutic drug monitoring.

Do not ration doses, borrow medicine, change from capsules to liquid, or restart a previously supplied medicine without discussing it with your specialist team. Itraconazole also has important interactions with other medicines.

What to do if you are running low

Do not wait until your final few doses. As soon as you think your supply may run out, contact the team that prescribes your antifungal medicine. Depending on your local arrangements, this may be your specialist nurse, hospital pharmacy, respiratory clinic or GP practice.

When you call or email, it helps to say:

the name, strength and formulation of the medicine;
how many doses you have left;
where you normally obtain it;
whether a pharmacy has told you it cannot obtain stock; and
any upcoming travel or other reason you will not be able to receive a delivery.

If you already use homecare and a planned delivery has not arrived, contact the homecare provider promptly and let your prescribing hospital team know if you are approaching the end of your supply. The hospital’s homecare pharmacy team can often help resolve problems with a prescription or delivery.

Planning ahead

Ask your team what buffer stock is appropriate for you and reorder or respond to delivery contacts promptly. Keep the homecare provider and hospital team updated if your telephone number, address, holiday plans or preferred delivery arrangements change.

For planned travel abroad, ask well in advance about extra supplies, storage requirements and a travel letter. Do not assume that a provider can deliver medicines outside the UK.

The key message

If obtaining itraconazole has become a repeated problem, you do not need to solve it alone by phoning around pharmacies. Ask your specialist team or hospital pharmacy whether an NHS medicines homecare pathway is suitable for your treatment. It may not remove every supply problem, but it can provide a safer and more convenient route for some people on long-term specialist antifungal treatment.

Further information

This information is for general guidance and does not replace advice from the clinician or pharmacist who prescribes your antifungal treatment.

by GAtherton

Clinician reviewing immune-suppressing medicines and blood test results alongside lung and Aspergillus imagery.

Immune-Suppressing Medicines and Aspergillosis: When Does Treatment Change the Risk?

Immune-suppressing medicines are used to control inflammation, prevent rejection after transplant and treat many serious conditions. They can be life-changing or lifesaving treatments.

Because they reduce part of the immune response, they can also increase susceptibility to infection. In a small number of people—usually where immune suppression is substantial or several risk factors combine—this may include invasive aspergillosis.

Most people taking a short course of steroids or a single immune-suppressing medicine will not develop invasive aspergillosis. Risk depends on the medicine, dose, duration, combination of treatments, white blood cell count, underlying condition and any existing lung damage.

What are immune-suppressing medicines?

These medicines reduce or alter immune activity. They are prescribed for many different reasons, including autoimmune disease, severe inflammatory illness, cancer treatment and organ or stem-cell transplant.

Examples include:

Corticosteroids, such as prednisolone, dexamethasone and methylprednisolone
Anti-rejection medicines, such as tacrolimus, ciclosporin, sirolimus and mycophenolate
Chemotherapy and some other cancer treatments that lower white blood cell counts
Biologic and targeted medicines used for conditions such as rheumatoid arthritis, inflammatory bowel disease, psoriasis and severe inflammatory disease
Other medicines used to suppress the immune system after transplant or to treat graft-versus-host disease

These groups of medicines work in different ways. They do not all carry the same infection risk, and they should never be stopped without advice from the team that prescribed them.

When does the risk of invasive aspergillosis increase?

Risk rises most when immune suppression is strong, prolonged or combined with other factors. Examples include:

High-dose or long-term steroid treatment
Several immune-suppressing medicines used together
Very low neutrophil counts (neutropenia), often during treatment for blood cancer
Stem-cell or organ transplant treatment
Treatment for graft-versus-host disease
Previous invasive fungal infection
Severe viral pneumonia, critical illness or intensive care treatment
Significant structural lung disease alongside immune suppression

For most people with inflammatory or autoimmune disease, the main concern is common infections rather than invasive aspergillosis. Your specialist team will assess whether your particular treatment plan creates a higher risk.

Why steroids deserve particular attention

Steroids are very effective at reducing inflammation and are used in many conditions. Their effect on infection risk depends on the dose, how long they are taken and whether other immune-suppressing medicines are used at the same time.

Short courses are common and usually do not create the same level of risk as high-dose or prolonged treatment. The risk is more relevant when steroids are used for weeks or months, at higher doses, or alongside other treatments that weaken immune defences.

Do not stop steroids suddenly unless your medical team tells you to. Stopping too quickly can be dangerous and may cause the underlying condition to flare.

How does this relate to other forms of aspergillosis?

Invasive aspergillosis is different from chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA).

Invasive aspergillosis usually occurs when immune defences are severely weakened and can develop quickly.
CPA usually develops gradually over months in lungs already damaged by conditions such as COPD, previous tuberculosis, sarcoidosis or bronchiectasis.
ABPA is an allergic reaction to Aspergillus, most often in people with asthma or cystic fibrosis.

Some people have more than one risk factor. For example, someone with COPD and damaged lungs who needs prolonged steroids may need their respiratory team to consider both their underlying lung condition and the effects of treatment.

How do specialist teams reduce the risk?

Your team may use several approaches depending on the condition being treated and your individual level of risk. These can include:

Using the lowest effective dose for the shortest appropriate time
Regular blood tests to monitor white blood cell counts, liver and kidney function
Vaccination planning and advice about infection prevention
Preventive antifungal treatment in selected high-risk situations
Rapid assessment of fever, new respiratory symptoms or unexplained illness

Preventive antifungal medication is not needed for everyone taking immune-suppressing treatment. It is generally reserved for people at clearly higher risk because antifungal medicines can have side effects and interact with other important drugs.

Symptoms that need prompt advice

Follow the advice and emergency contact plan provided by your own specialist team. Contact them promptly if you have a fever or feel significantly more unwell while taking immune-suppressing medicines.

Symptoms that may need assessment include:

Fever that persists, returns or does not improve as expected
New or worsening cough
Increasing breathlessness
Chest pain, especially pain that is worse when breathing in
Coughing up blood
Severe fatigue or unexplained deterioration

These symptoms have many possible causes and do not mean that someone has aspergillosis. But prompt assessment matters when the immune system is significantly suppressed.

What you can do

Keep an up-to-date list of every medicine you take, including the dose and any treatment given by another hospital or clinic. Tell your specialist team about new symptoms, and ask what your individual infection risks are before starting a new immune-suppressing treatment.

Do not stop, reduce or change immune-suppressing medicines without medical advice. If you have been prescribed antifungal prevention, take it exactly as instructed and ask about possible interactions before starting any new medicine, supplement or herbal treatment.

Related information

Sources: IDSA aspergillosis guidance; NHS inform: corticosteroids; NHS guidance for people taking biologic medicines.

by GAtherton

Medical illustration of a clinician reviewing chest CT imaging after organ transplant, with lung, kidney, liver and heart transplant context.

Organ Transplant and Aspergillosis: Understanding Infection Risk

An organ transplant can be life-changing treatment for severe organ failure. To protect the new organ, people need anti-rejection medicines that reduce the activity of the immune system.

These medicines can also make some infections more likely, including the uncommon but serious fungal infection invasive aspergillosis. Risk varies greatly by the transplanted organ, the medicines used, the time since transplant and any complications such as rejection.

This article is for people who have had, or are preparing for, a solid-organ transplant. Invasive aspergillosis is not the form of aspergillosis usually associated with asthma, COPD, bronchiectasis or ordinary mould exposure at home.

Why transplant treatment can increase the risk

We all breathe in tiny Aspergillus spores from the environment. In most people, the immune system clears them without difficulty.

After an organ transplant, anti-rejection medicines deliberately reduce immune activity so that the body does not attack the new organ. High doses of steroids or stronger immune-suppressing treatment may sometimes be needed, particularly soon after transplant or during treatment for rejection.

This can create an opportunity for Aspergillus to grow into lung tissue and cause invasive aspergillosis.

Does risk differ between transplant types?

Yes. The risk is not the same for everyone.

Lung transplant

Lung transplant recipients have particular reasons for careful monitoring. The transplanted lungs are directly exposed to inhaled spores, and the airways may take time to heal after surgery. Aspergillus can sometimes be found in airway samples without causing invasive disease, but it still needs careful assessment by the transplant team.

Different transplant centres use different approaches to antifungal prevention and monitoring after lung transplant. Decisions take account of local fungal patterns, previous cultures, airway healing, medication interactions and individual risk factors.

Liver transplant

Invasive aspergillosis remains uncommon after liver transplant. Risk may be higher in people who are very unwell around the time of transplant, need kidney replacement treatment, have a repeat transplant or require stronger immune-suppressing treatment.

Kidney and heart transplant

For most kidney and heart transplant recipients, invasive aspergillosis is uncommon. The risk can rise if there is severe immune suppression, treatment for rejection, low white blood cell counts, serious infection, diabetes or significant lung disease.

Your transplant team assesses these factors when deciding whether extra monitoring or preventive antifungal treatment is needed.

Colonisation and invasive infection are not the same

In people with lung transplants, Aspergillus may sometimes be found in sputum or samples taken during bronchoscopy. This can be called colonisation: the fungus is present, but there is no clear evidence that it has invaded tissue or is causing illness.

Colonisation does not automatically mean that someone has invasive aspergillosis or needs the same treatment. However, it is important information for the transplant team because it may influence monitoring, repeat testing or preventive treatment.

How teams reduce the risk

Transplant teams plan for infection risk from the beginning. Depending on the transplant type and individual circumstances, this may include:

Preventive antifungal medication during higher-risk periods
Regular blood tests and review of drug levels
Routine respiratory samples or bronchoscopy after lung transplant
Review of chest imaging when symptoms or test results suggest infection
Careful adjustment of anti-rejection medicines and antifungal treatment to avoid serious drug interactions

Prevention is not one-size-fits-all. In particular, antifungal medicines can interact strongly with anti-rejection medicines such as tacrolimus, ciclosporin, sirolimus or everolimus. This is one reason why treatment and monitoring need to be managed by the transplant team.

Symptoms that need urgent discussion

Contact your transplant team promptly if you feel unwell or develop new symptoms. Follow the emergency contact instructions supplied by your transplant centre.

Possible symptoms of invasive aspergillosis include:

Fever, particularly if it persists or returns despite antibiotic treatment
New or worsening cough
Breathlessness
Chest pain, especially pain that is worse when breathing in
Coughing up blood
Marked tiredness or a general deterioration without a clear cause

These symptoms can have many possible causes, including viral or bacterial infection, medication effects, rejection or other transplant complications. They do not mean that someone has aspergillosis, but they need prompt assessment while immune defences are reduced.

How is invasive aspergillosis investigated?

Tests may include:

Blood tests, including checks of white blood cell counts and organ function
Chest X-ray and CT scanning
Blood tests for fungal markers, such as galactomannan or beta-D-glucan
Sputum or airway samples
Bronchoscopy, particularly after lung transplant, when it is safe and likely to help

The transplant, infectious diseases, respiratory, microbiology and pharmacy teams may work together to interpret the results and decide on treatment.

Treatment

Invasive aspergillosis requires specialist treatment. Antifungal medicines such as voriconazole, posaconazole or isavuconazole may be used, depending on the individual situation.

Treatment can last for weeks or months. Drug levels, liver and kidney function, side effects and interactions with anti-rejection medicines all need careful monitoring. The transplant team will balance infection control with protecting the transplanted organ.

What you can do

Take anti-rejection and antifungal medicines exactly as prescribed. Do not stop, start or change medicines without speaking to your transplant team, including medicines bought over the counter or prescribed by another service.

Keep the emergency contact details from your transplant centre easy to find. If you are unsure about your own risk, ask which medicines affect your immune system most, whether you are receiving antifungal prevention and which symptoms should prompt an urgent call.

Related information

Source: IDSA 2026 guidance on prevention of invasive aspergillosis in adult solid-organ transplant recipients.

by GAtherton

Medical illustration of immune-cell recovery after stem-cell transplant alongside chest CT monitoring for invasive aspergillosis.

Stem-Cell (Bone Marrow) Transplant and Aspergillosis

A stem-cell transplant, sometimes called a bone marrow transplant, can be an important treatment for blood cancers and some serious blood or immune-system conditions. It replaces damaged or diseased bone marrow with healthy blood-forming stem cells.

For a time, the treatment also leaves the immune system much weaker than usual. This makes infections more likely, including the uncommon but serious fungal infection invasive aspergillosis.

This article is for people having, or recovering from, a stem-cell transplant. Invasive aspergillosis is a specific risk when immune defences are severely weakened. It is not the form of aspergillosis usually associated with asthma, COPD, bronchiectasis or ordinary mould exposure at home.

Why transplant treatment can increase the risk

We all breathe in tiny Aspergillus spores from the environment. In most people, immune cells remove them before they cause harm.

Before a stem-cell transplant, intensive treatment known as conditioning is used to prepare the body. This can reduce the number of infection-fighting white blood cells, especially neutrophils. It may take time for the transplanted stem cells to begin producing enough new blood cells and for the immune system to recover.

The risk is not the same throughout transplant. Your transplant team assesses it at each stage and may use preventive antifungal treatment, blood tests and other monitoring.

When is the risk highest?

Before engraftment: very low white blood cell counts

In the first weeks after conditioning and transplant, white blood cell counts can be very low. This is called neutropenia. During this period, the body has fewer neutrophils to control infections, including invasive fungal infections.

People are usually monitored closely in hospital at this stage. Fever or feeling unwell is taken seriously and should be reported immediately.

Early immune recovery

As the transplant begins to work, blood counts recover. This is known as engraftment. The risk of infection usually falls, but the immune system is still rebuilding and may not work normally for some time.

Previous infections, ongoing treatment, complications and the type of transplant can all affect individual risk.

Later after an allogeneic transplant

An allogeneic transplant uses stem cells from a donor. Some people develop graft-versus-host disease (GvHD), where donor immune cells attack parts of the recipient’s body.

Treatment for GvHD may include steroids or other medicines that suppress the immune system. This can increase the risk of invasive aspergillosis again, sometimes months after the transplant. The risk can remain higher while significant GvHD or immune-suppressing treatment continues.

Autologous and allogeneic transplants

An autologous transplant uses a person’s own stem cells. The main period of infection risk is usually the early phase when blood counts are low.

An allogeneic transplant uses donor stem cells. It can involve a longer period of immune suppression, particularly if GvHD develops or needs treatment. Your transplant team can explain what this means for your individual plan.

How teams reduce the risk

Transplant teams expect infection risk and plan for it. Depending on your treatment and risk factors, this may include:

Preventive antifungal medication during higher-risk periods
Regular blood tests and close review of symptoms
Advice on food safety, hand hygiene and avoiding contact with people who are unwell
Vaccination planning after immune recovery
Rapid investigation of fever, cough, breathlessness or other possible signs of infection

Follow the guidance from your own transplant centre. Recommendations vary according to the type of transplant, blood counts, other medicines and local clinical protocols.

Symptoms that need urgent discussion

During transplant treatment or while taking immune-suppressing medicine, contact your transplant or haematology team urgently if you develop a fever or feel significantly unwell. Use the emergency contact details they have given you.

Possible symptoms of invasive aspergillosis include:

Fever that does not settle, returns or continues despite antibiotic treatment
New or worsening cough
Breathlessness
Chest pain, especially pain that is worse when breathing in
Coughing up blood
Severe tiredness or unexplained deterioration

These symptoms have many possible causes. They do not mean that someone has aspergillosis, but prompt assessment is important because infections can become serious quickly when immune defences are low.

How is invasive aspergillosis investigated?

Diagnosis can be challenging because symptoms and scan changes can overlap with other infections, medication effects and transplant complications. Tests may include:

Blood tests and regular checks of blood counts
Chest X-ray and CT scanning
Blood tests for fungal markers, such as galactomannan or beta-D-glucan
Sputum or airway samples, where available
Bronchoscopy or other procedures when they are safe and likely to help

The transplant, infectious diseases, respiratory, microbiology and pharmacy teams may work together to interpret results and plan treatment.

Treatment

Invasive aspergillosis needs specialist treatment. Antifungal medicines such as voriconazole or isavuconazole are commonly used, but the choice depends on the individual situation and any possible interactions with transplant medicines.

Treatment may continue for weeks or months. It is guided by symptoms, scans, test results and recovery of the immune system. Drug levels, kidney and liver function, and possible side effects may need close monitoring.

What you can do

Keep the emergency numbers from your transplant team easy to find and follow their advice about infection prevention. Do not stop antifungal prevention or immune-suppressing medicines without discussing this with your team.

If you are unsure about your own risk, ask your transplant team which phase of recovery you are in, whether you are receiving antifungal prevention and which symptoms should prompt an urgent call.

Related information

Sources: American Society of Transplantation and Cellular Therapy guidance on aspergillosis in haematopoietic cell transplant recipients; Review of fungal infections in haematopoietic stem-cell transplant recipients; Anthony Nolan information on infection after stem-cell transplant.

by GAtherton

Clinician reviewing a chest CT scan and respiratory sample for Aspergillus during severe viral pneumonia in hospital.

Flu, COVID-19 and Aspergillosis: When Severe Viral Pneumonia Changes the Risk

Flu (influenza) and COVID-19 can be particularly difficult for people with lung conditions. They may worsen cough, breathlessness, fatigue or asthma symptoms, and can sometimes lead to pneumonia or a flare of an existing lung disease.

Very rarely, severe viral pneumonia can also be complicated by a type of invasive aspergillosis. This is mainly a concern for people who are seriously ill in hospital, particularly in intensive care. It is not something that usually follows an ordinary flu-like illness or a positive COVID-19 test managed at home.

This article is about severe viral pneumonia in hospital or intensive care. It does not mean that people with asthma, COPD, bronchiectasis, ABPA or CPA will develop invasive aspergillosis whenever they catch flu or COVID-19.

Why can severe viral pneumonia increase the risk?

Most people breathe in tiny Aspergillus spores every day without becoming ill. The lining of the airways, mucus clearance and immune system normally stop the spores from causing infection.

Severe influenza or COVID-19 pneumonia can damage the lining of the airways and lungs. In people who are critically unwell, this damage may combine with other factors such as intensive care treatment, mechanical ventilation, prolonged steroid treatment or a weakened immune system. This can create an opportunity for Aspergillus to grow into lung tissue.

This is called invasive pulmonary aspergillosis.

IAPA and CAPA

Doctors sometimes use specific names for invasive aspergillosis linked with severe viral pneumonia:

IAPA — influenza-associated pulmonary aspergillosis
CAPA — COVID-19-associated pulmonary aspergillosis

Both conditions are mainly recognised in people admitted to hospital with severe viral pneumonia, especially those needing critical care. They are different from chronic pulmonary aspergillosis (CPA), which develops gradually over months in structurally damaged lungs, and from ABPA, which is an allergic reaction to Aspergillus.

Who is most likely to be affected?

Severe influenza or COVID-19 pneumonia is the main concern. The risk may be higher in people who also have:

A very weakened immune system, for example because of blood cancer treatment or transplant medicines
Prolonged or high-dose steroid treatment
Serious underlying lung disease
Other severe illness requiring intensive care treatment

However, IAPA has also been reported in some critically ill people with influenza who did not have a previously recognised immune problem. This is why intensive care teams remain alert to the possibility when severe viral pneumonia is not improving as expected.

What symptoms or changes make doctors investigate?

People with severe viral pneumonia are already being closely monitored in hospital. Doctors may consider invasive aspergillosis if there is a persistent or returning fever, worsening breathing, new changes on a chest CT scan, or deterioration despite treatment for the viral infection and possible bacterial infection.

These changes can have many explanations. They do not automatically mean that someone has aspergillosis. Testing is needed because viral pneumonia, bacterial infection, inflammation and invasive aspergillosis can look similar.

How is it investigated?

Assessment may include:

Chest X-ray and CT scanning
Blood tests for fungal markers, such as galactomannan or beta-D-glucan
Testing sputum or samples from the airways
Bronchoscopy, when it is safe and likely to provide useful information
Review by critical care, respiratory, infectious diseases and microbiology teams

No one test answers every question. Teams interpret the results alongside the severity of illness, scan findings, other infections and any treatments that affect the immune system.

Treatment

When invasive aspergillosis is suspected or confirmed, treatment is coordinated by specialist hospital teams. Antifungal medicines such as voriconazole or isavuconazole are commonly used, with the choice depending on the individual situation, other medicines and kidney and liver function.

Prompt diagnosis and treatment are important, but care also includes treating the viral pneumonia, supporting breathing and managing any other infections or medical problems.

What this means for people living with chronic lung disease or aspergillosis

Flu and COVID-19 can still be significant infections for people with asthma, COPD, bronchiectasis, ABPA or CPA. They may trigger a flare of existing symptoms or lead to a chest infection, so it is sensible to follow your usual action plan and seek medical advice if you are becoming more unwell.

But invasive aspergillosis after flu or COVID-19 is not the expected outcome of an ordinary respiratory virus. The terms IAPA and CAPA mainly describe a rare complication of severe viral pneumonia in hospital.

Prevention

Vaccination is an important way of reducing the chance of severe respiratory infection. Keep up to date with flu and COVID-19 vaccines if they are recommended for you, and ask your GP, pharmacist or specialist team if you are unsure about eligibility.

Vaccines do not treat aspergillosis directly. Their value in this context is that preventing severe influenza or COVID-19 also reduces the chance of the serious complications that can follow severe viral pneumonia.

Related information

Sources: Review of influenza-associated and COVID-19-associated pulmonary aspergillosis; ECMM/ISHAM guidance on COVID-19-associated pulmonary aspergillosis; NHS COVID-19 vaccination information.

by GAtherton

Clinician reviewing blood test results and a chest CT scan for invasive aspergillosis during blood cancer treatment.

Blood Cancer and Aspergillosis: Understanding Invasive Aspergillosis

People being treated for blood cancer are at increased risk of infection because the cancer itself, chemotherapy and some other treatments can reduce the number or function of infection-fighting white blood cells.

One uncommon but serious infection is invasive aspergillosis. Unlike chronic pulmonary aspergillosis, which usually develops slowly in already damaged lungs, invasive aspergillosis can develop more quickly when immune defences are severely weakened. It needs prompt specialist assessment and treatment.

This information is mainly for people receiving treatment that significantly weakens the immune system. Invasive aspergillosis is not the form of aspergillosis usually associated with asthma, COPD, bronchiectasis or ordinary mould exposure at home.

Why blood cancer treatment can increase the risk

We all breathe in tiny Aspergillus spores from the environment. In most people, immune cells clear them before they cause a problem.

Blood cancers and their treatment can sometimes reduce these defences. The most important risk is neutropenia: a low level of neutrophils, a type of white blood cell that helps the body control many infections.

The risk may be higher during or after:

Treatment for acute leukaemia, particularly intensive chemotherapy
Treatment for relapsed or difficult-to-treat blood cancer
Some treatments for lymphoma or myeloma
Long periods of low white blood cell counts
High-dose steroid treatment or other medicines that suppress the immune system
Stem-cell (bone marrow) transplant treatment

Risk varies greatly between people and between treatment plans. Your haematology team will know when your blood counts and treatment make infection more likely.

What is invasive aspergillosis?

In invasive aspergillosis, Aspergillus grows into lung tissue rather than simply being present in the airways. The lungs are most often affected, but infection can occasionally spread to other parts of the body.

This is different from:

ABPA, an allergic reaction to Aspergillus that mainly affects people with asthma or cystic fibrosis
CPA, a long-term infection that usually develops over months in structurally damaged lungs
Colonisation, where Aspergillus is found in a sample without clear evidence that it is causing illness

How teams reduce the risk

Haematology and transplant teams take the risk of infection seriously. Depending on the type of treatment and the expected duration of neutropenia, they may use antifungal medicines to prevent mould infections, arrange regular blood tests and advise when urgent assessment is needed.

You may also be given practical advice about food safety, avoiding contact with people who are unwell and when to contact the hospital. Follow the advice from your own treatment team, as it will be tailored to your blood counts and treatment plan.

Symptoms that need urgent discussion

During treatment for blood cancer, a fever or feeling unwell can be an emergency because infections may become serious quickly. Follow the emergency contact instructions given by your haematology team.

Possible symptoms of invasive aspergillosis include:

Fever, particularly one that does not settle or returns despite antibiotic treatment
New or worsening cough
Breathlessness
Chest pain, especially pain that is worse when breathing in
Coughing up blood
Severe tiredness or a general deterioration without a clear cause

These symptoms can have many causes, including bacterial or viral infections, treatment effects and the blood cancer itself. They do not mean that someone has aspergillosis. But they should be assessed promptly, especially during neutropenia or when taking immune-suppressing treatment.

How is invasive aspergillosis investigated?

Diagnosis can be difficult because early symptoms are often non-specific and respiratory samples may not always be available. Tests may include:

Blood tests and repeated checks of blood counts
A chest CT scan
Blood tests for fungal markers, such as galactomannan or beta-D-glucan
Sputum testing, where a sample can be produced
Bronchoscopy or other procedures when these are safe and likely to help

Doctors interpret these results together. No single blood test, scan or culture proves every case, and treatment may need to begin before every test result is available when the clinical concern is high.

Treatment

Invasive aspergillosis is treated by specialist haematology, infectious diseases and respiratory teams. Antifungal medicines such as voriconazole or isavuconazole are commonly used, with the choice tailored to the individual situation.

Treatment is often given for weeks or months and continues until the infection is controlled and immune recovery allows the body to help clear it. Drug levels, liver and kidney function, side effects and interactions with cancer medicines may all need close monitoring.

What you can do

Keep the emergency contact numbers supplied by your haematology team easy to find. Contact them promptly if you develop a fever or feel significantly unwell during treatment, even if symptoms seem minor.

Do not stop antifungal prevention or other prescribed treatment without discussing it with your team. If you have questions about your individual risk, ask when your white blood cell count is expected to be lowest and what symptoms should prompt an urgent call.

Related information

Sources: ECIL guidance on invasive fungal disease in cancer and transplant patients; IDSA aspergillosis guidance; Blood Cancer UK information on neutropenia and infection.

by GAtherton

Clinician comparing chest CT scans with lung nodules, illustrating careful assessment for lung cancer or Aspergillus-related disease.

Lung Cancer and Aspergillosis: When Symptoms and Scan Changes Need Careful Assessment

Lung cancer and aspergillosis can sometimes occur in the same person, but having lung cancer does not mean that someone will develop a fungal infection. Aspergillosis is still uncommon.

It becomes important to consider when lung cancer, previous lung disease or cancer treatment has changed the structure of the lungs or weakened the body’s ability to control infection. Symptoms and scan changes can then be difficult to interpret: they may be due to cancer, treatment effects, bacterial infection or an Aspergillus-related lung condition.

Why lung cancer can change the risk

Most people breathe in Aspergillus spores without becoming ill. Healthy lungs and immune defences normally clear them.

For some people with lung cancer, several factors can combine to make aspergillosis more likely:

Underlying COPD, emphysema, bronchiectasis, previous tuberculosis or other lung damage
Surgery that removes part of the lung or leaves an altered area of lung structure
Radiotherapy, which can sometimes cause scarring or damage to lung tissue over time
Chemotherapy, prolonged steroid treatment or other medicines that suppress immune defences
Reduced lung function, weight loss or general frailty during cancer treatment

These factors do not cause aspergillosis on their own. They change the balance between the fungus, the lungs and the immune system.

Which forms of aspergillosis can occur?

The type of aspergillosis depends largely on lung structure and immune status.

Chronic pulmonary aspergillosis (CPA)

CPA is a long-term infection that usually develops over months in lungs that are already damaged. It can cause cavities, scarring or nodules, sometimes with an aspergilloma (fungal ball) in a cavity. CPA may occur months or years after surgery or radiotherapy for lung cancer.

Invasive aspergillosis

Invasive aspergillosis is a more serious infection in which the fungus damages lung tissue and may spread beyond the lungs. It is more likely when the immune system is very weakened, for example during some intensive chemotherapy treatments, prolonged high-dose steroid treatment or treatment for blood cancers.

Aspergillus colonisation

Sometimes Aspergillus is found in sputum without clear evidence that it is causing disease. This is called colonisation. A positive culture needs to be interpreted alongside symptoms, scans and blood tests; it does not automatically mean that antifungal treatment is needed.

Why diagnosis can be difficult

Lung cancer, surgery, radiotherapy, bacterial infection and aspergillosis can all cause cough, breathlessness, tiredness, weight loss and changes on a CT scan. A new nodule, cavity or area of shadowing may need careful investigation to distinguish between cancer recurrence, treatment-related change and infection.

An aspergilloma can also be mistaken for lung cancer on imaging. A fungal ball inside a cavity, or an Aspergillus nodule, may appear as a mass or nodule on a chest X-ray, CT scan or PET scan. Equally, a new cancer can sometimes be mistaken for infection. This is why doctors may need to compare scans over time and use blood tests, respiratory samples or a biopsy before reaching a diagnosis.

Aspergillosis can mimic lung cancer on a scan. An Aspergillus nodule or an aspergilloma may look like a lung mass, while cancer or cancer recurrence can sometimes resemble infection. Careful specialist assessment helps avoid premature conclusions in either direction.

Diagnosis usually combines several sources of information:

Symptoms and the timeline of cancer treatment
Comparison of current and previous chest CT scans
Blood tests, including Aspergillus IgG antibodies when CPA is suspected
Sputum or bronchoscopy samples, where appropriate
Additional imaging or biopsy when the diagnosis remains uncertain

No single test gives every answer. A specialist respiratory, oncology and fungal infection team may need to review the findings together.

Symptoms that should be discussed promptly

Let your cancer or respiratory team know about symptoms that are new, worsening or not improving as expected. These include:

Persistent or worsening cough
Increasing breathlessness
Fever or repeated chest infections
Ongoing fatigue or unexplained weight loss
Chest pain or discomfort
Coughing up blood (haemoptysis)

Coughing up blood should always be reported. Seek urgent medical help for significant, repeated or rapidly increasing bleeding.

Treatment needs to be coordinated

If aspergillosis is diagnosed, treatment depends on the type of infection, the extent of lung disease, immune status and the cancer treatment plan.

CPA is often treated with long-term antifungal medication and regular monitoring. Invasive aspergillosis needs urgent specialist treatment. An aspergilloma causing significant bleeding may sometimes be treated with surgery or a procedure to block the bleeding blood vessels.

Antifungal medicines can interact with some cancer treatments and other medicines. It is therefore important that the oncology, respiratory and pharmacy teams know about every medicine being taken before treatment starts or changes.

What you can do

Keep attending planned cancer and respiratory follow-up appointments, and report symptoms rather than assuming they are simply part of recovery or treatment.

Aspergillosis is not the most likely explanation for a new symptom or scan change in someone with lung cancer. But a history of lung cancer and its treatment is important information when clinicians are considering persistent symptoms, cavities, nodules or unexplained changes on a scan.

Related information

Sources: ERS/ESCMID clinical guidelines for chronic pulmonary aspergillosis; European Respiratory Society review of pulmonary aspergillosis.

by GAtherton

Medical illustration of lung bullae and a clinician reviewing a chest CT scan for Aspergillus-related changes.

Pneumothorax, Bullae and Aspergillosis: Why Old Lung Damage Can Matter

A pneumothorax is a collapsed lung. It happens when air enters the space between the lung and the chest wall, causing part or all of the lung to collapse. A bulla is a large air-filled space within the lung, most often linked with emphysema or other structural lung damage.

Most people who have had a pneumothorax or have bullae will never develop aspergillosis. However, these conditions can be part of the lung history that makes chronic pulmonary aspergillosis (CPA) more likely in a small number of people.

The important issue is not the past event alone. It is whether it has left an area of damaged, scarred or poorly functioning lung in which Aspergillus can persist.

Why lung structure matters

Everyone breathes in tiny Aspergillus spores from the environment. Healthy lungs normally clear them without difficulty.

When airways or lung tissue are already damaged, mucus may be harder to clear and the lung can contain spaces where spores can settle. Over time, Aspergillus may grow in these areas. This can lead to CPA or, in some cases, an aspergilloma—a fungal ball within an existing cavity or air space.

Bullae and cavities are not the same thing. A bulla is an enlarged air space caused by destruction of lung tissue, whereas a cavity usually develops within an area of abnormal lung tissue. But both can be signs that lung structure has changed, and both may be relevant when a doctor is investigating persistent symptoms or unusual scan findings.

Pneumothorax and Aspergillus

A previous pneumothorax does not mean that Aspergillus caused the collapse, or that aspergillosis will develop afterwards. In most cases it will not.

However, pneumothorax can occur alongside bullae, emphysema, previous infection or other lung conditions that have already changed the structure of the lungs. It may also lead to surgery or pleural procedures. This wider lung history is why clinicians may consider CPA if symptoms persist or scans later show a cavity, progressive scarring or a possible fungal ball.

Bullae, emphysema and COPD

Bullae are often associated with emphysema and COPD. They can vary greatly in size and effect on breathing. Some remain stable for years; others are part of more extensive lung damage.

COPD and emphysema are recognised underlying conditions for CPA. This does not mean that a bulla becomes infected simply because it exists. Rather, structural damage, reduced mucus clearance, repeated infection, steroid treatment and other aspects of lung health can combine to create a more favourable environment for Aspergillus.

Symptoms that should be checked

CPA usually develops slowly, over at least several months. Its symptoms can overlap with COPD, emphysema, recovery from pneumothorax or recurrent chest infection.

Speak to your respiratory team if you notice:

A cough that persists or becomes worse
Increasing breathlessness beyond your usual level
Persistent tiredness, low energy or unintentional weight loss
Recurrent chest infections or symptoms that do not settle as expected
Chest discomfort
Coughing up blood (haemoptysis)

A small streak of blood in sputum can have several causes, but should always be reported. Seek urgent medical help for significant, repeated or rapidly increasing bleeding.

How is aspergillosis investigated?

A previous pneumothorax or bulla is only one piece of the picture. Doctors usually need to combine several types of information:

Symptoms and the history of previous lung problems
Chest X-ray and, usually, a CT scan
Blood tests, including Aspergillus IgG antibodies
Sputum testing, where a sample can be produced
Comparison with previous scans to see whether a change is stable or progressing

CPA is not diagnosed from one scan finding or a single positive sputum sample alone. Specialists look for consistent evidence of Aspergillus-related disease, usually with symptoms or progressive imaging changes lasting at least three months, while ruling out other causes.

Treatment and monitoring

Some people with bullae or old pneumothorax-related changes only need routine follow-up for their underlying lung condition. A stable bulla or scar is not treated as aspergillosis.

If CPA is diagnosed, treatment may include antifungal medication, often with regular blood tests and scans. Treatment is tailored to the type of aspergillosis, the amount of healthy lung remaining and any other medicines being taken.

If a fungal ball is causing significant bleeding and is single and localised, surgery may sometimes be an option. Where surgery is not suitable, other approaches may include antifungal treatment or bronchial artery embolisation—a procedure that can help control bleeding.

What you can do

Keep attending planned follow-up after a pneumothorax or lung surgery, and make sure your respiratory team knows about any change from your usual symptoms.

A previous collapsed lung or bullae do not mean aspergillosis is inevitable. But if you have persistent symptoms, worsening scans or coughing up blood, mention your full lung history and ask whether Aspergillus needs to be considered.

Related information

Source: Smith NL, Denning DW. Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma. European Respiratory Journal.

by GAtherton