Bronchiectasis is a chronic lung condition where the airways (bronchi) become damaged, widened, and scarred, making it harder to clear mucus properly.

🫁 What Happens in Bronchiectasis?

  • Normally, your airways move mucus (with trapped bacteria and dust) out of the lungs using tiny hairs called cilia.

  • In bronchiectasis, the airway walls are damaged and permanently widened.

  • This leads to mucus buildup, which creates a cycle of infection, inflammation, and further airway damage.

🧾 Common Symptoms

  • Chronic cough with daily mucus production (can be clear, yellow, green)

  • Frequent chest infections

  • Breathlessness or wheezing

  • Fatigue

  • Coughing up blood (haemoptysis) in some cases

  • Throat irritation or constant throat clearing (especially if mucus pools or reflux occurs)

⚠️ Causes of Bronchiectasis

It may result from:

  • Severe or repeated chest infections (e.g., pneumonia, TB)

  • Underlying lung diseases (like ABPA, asthma, or COPD)

  • Immune system problems

  • Cystic fibrosis (a genetic form)

  • Non-tuberculous mycobacteria (NTM) infections

  • Sometimes, no cause is found (idiopathic bronchiectasis)

🩺 How Is It Diagnosed?

  • High-resolution CT scan of the chest (gold standard)

  • Blood tests, sputum cultures

  • Lung function tests (spirometry)

  • Tests for underlying conditions like ABPA or immunodeficiency

🛠️ Treatment Goals

  • Clear mucus: chest physiotherapy, airway clearance techniques

  • Control infection: antibiotics when needed

  • Reduce inflammation: inhalers or steroids (if overlapping asthma/ABPA)

  • Address underlying cause, if known

The relationship between bronchiectasis and ABPA (Allergic Bronchopulmonary Aspergillosis) is not symmetrical.

✅ ABPA causes bronchiectasis — not the other way around.

🔁 Here’s how it works:

  1. ABPA is an allergic reaction to the Aspergillus fungus (commonly A. fumigatus) in people with asthma or cystic fibrosis.

  2. This allergic reaction causes:

    • Inflammation in the airways

    • Mucus plugging

    • Repeated airway damage

  3. Over time, this chronic inflammation and mucus blockage damages the bronchial walls → leading to central bronchiectasis, a classic feature of ABPA.

🔬 Diagnostic Clue:

  • Central bronchiectasis (bronchiectasis near the centre of the chest) on CT is considered a key imaging sign of ABPA.

  • If bronchiectasis is peripheral or widespread, another cause is more likely.

Summary:

  • ABPA can cause bronchiectasis, especially if not diagnosed early or if poorly controlled.

  • Bronchiectasis does not cause ABPA, but patients with bronchiectasis may become colonised with Aspergillus, which can confuse the picture — this is not the same as ABPA.

If I have both, how can I tell if a symptom is caused by ABPA or bronchiectasis?

ABPA and bronchiectasis often overlap, but they have different underlying mechanisms and treatment approaches, so understanding which condition is driving your symptoms can help guide better management.

Here’s a breakdown to help you distinguish:

🩺 ABPA vs Bronchiectasis: Symptom Comparison

Symptom More Likely ABPA More Likely Bronchiectasis
Worsening asthma ✅ Frequent flare-ups despite treatment 🔸 Less common unless ABPA coexists
Wheezing ✅ Due to allergic airway inflammation 🔸 Can occur, but less prominent
Thick, brown or plug-like mucus ✅ Classic ABPA sign (mucus plugging) 🔸 Mucus usually looser, green/yellow
Fever & feeling unwell ✅ During flare-ups (“exacerbation”) 🔸 During infections
Cough with daily mucus 🔸 May occur in mild ABPA ✅ Very common and persistent
Recurrent chest infections 🔸 Possible if poorly controlled ✅ Hallmark of bronchiectasis
Coughing up blood (haemoptysis) ✅ Sometimes in ABPA ✅ Common in moderate/severe bronchiectasis
Crackles on chest exam 🔸 Less common ✅ Frequent finding
Raised IgE and eosinophils ✅ Diagnostic clue ❌ Not typical unless ABPA overlaps
CT scan shows central bronchiectasis ✅ Strong ABPA indicator ❌ Other patterns more likely
Worsens with steroid taper ✅ Suggests allergic nature ❌ Usually stable or infection-related

🧪 Tests to Help Differentiate

  • Total IgE: Usually >1000 IU/mL in ABPA

  • Aspergillus-specific IgE: Positive in ABPA

  • Aspergillus precipitins/IgG: Often raised in chronic forms or colonisation

  • Sputum culture: May show Aspergillus in either condition

  • High-Resolution CT: Can suggest central bronchiectasis (ABPA) vs widespread (other causes)

🔄 Key Point: You Can Have Both

Many people have both ABPA and bronchiectasis, especially if ABPA wasn’t diagnosed early. In these cases:

  • ABPA drives inflammation and allergic flare-ups

  • Bronchiectasis causes chronic mucus and infections

✅ What You Can Do

  • Track when and how symptoms worsen (after stopping steroids? with weather changes? during infections?)

  • Discuss blood tests and CT scan findings with your doctor

  • Ask whether biologic therapy or antifungals may be appropriate if ABPA is active

  • Make sure airway clearance techniques are part of your bronchiectasis care

NHS Bronchiectasis

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