Question: “I sat outside in the spring sunshine for 45 minutes in a t-shirt, trousers and a hat. I have now got a rash on both hands and arms. Is this due to me taking voriconazole? Any ideas what to do?”
☀️ Why the Rash Happened
Voriconazole is well known to cause photosensitivity reactions — even in mild sunlight and after short exposure. This happens because:
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The drug causes phototoxicity, meaning it reacts with UV-A and UV-B rays, damaging the skin directly.
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These reactions can be immediate (sunburn-like rash, redness, stinging) or delayed (itchy, scaly rash days later).
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It happens even in places with relatively low sun exposure — like Scotland/Northern Ireland/Northern England.
🔍 What the Rash Looks Like
Typical features of voriconazole-induced photosensitivity:
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Redness, itching, or stinging in sun-exposed areas (hands, arms, neck, face)
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Often clearly demarcated where clothes stop
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May blister or peel in more severe cases
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Can evolve into chronic skin damage with repeated exposure
✅ What to Do Now
1. Get out of the sun and monitor the rash
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Stay in the shade or indoors while the rash settles.
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Avoid more sun over the next few days.
2. Soothing relief
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Apply a cool compress or unscented moisturiser (e.g. E45, Cetraben).
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A mild topical steroid (like hydrocortisone 1%) may help if the rash is itchy — ask your GP or pharmacist.
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Antihistamines (e.g. loratadine or cetirizine) can reduce itching.
3. Contact your GP or specialist
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Let them know this happened — even if it settles.
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It may influence whether you continue voriconazole or switch to another antifungal (like posaconazole, which has less photosensitivity risk).
☂️ How to Protect Yourself in Future
If you stay on voriconazole:
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Always wear long sleeves and a wide-brimmed hat when outdoors — even in cloudy weather.
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Use a high-SPF sunscreen (SPF 50+) with UVA and UVB protection — but apply 30 minutes before sun exposure and reapply every 2 hours.
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Avoid sun between 11am–3pm if possible.
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Some people need to avoid sunlight through windows or in cars, especially on longer journeys.
🚨 When to Seek Urgent Help
Call your GP or 111 if:
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The rash is blistering, painful, or spreading
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You feel unwell (e.g. fever, chills)
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You develop ulcers or notice skin peeling
You’re definitely not alone — this is a very common side effect of voriconazole.
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