Izibalo zabantu abasengcupheni yokutheleleka ngesikhunta ziyanda ngenxa yokuguga kwabantu, ukwanda kokusetshenziswa kwemithi yokuzivikela komzimba, izimo zezokwelapha ezivele zikhona, izinguquko zemvelo, nezici zokuphila. Ngakho-ke, kunesidingo esikhulayo sokwelashwa okusha noma izinketho zokuvimbela.
Izinketho zamanje zokwelapha izifo zesikhunta ngokuvamile zihlanganisa ukusetshenziswa kwemithi ye-antifungal, njenge-azoles, i-echinocandins, ne-polyene. Le mithi ngokuvamile iyasebenza ekwelapheni izifo zefungal, kodwa ingaba nezinkinga ezithile. Isibonelo, ezinye izidakamizwa ze-antifungal zingasebenzisana neminye imithi, okuholela emiphumeleni engase ibe yingozi. Ukwengeza, ukusetshenziswa ngokweqile kwezidakamizwa ze-antifungal kungaba nomthelela ekwakhiweni kokumelana nemithi elwa namagciwane, okungenza ukwelashwa kube inselele.
Kube nentshisekelo ekhulayo ekuthuthukisweni kwemithi yokugoma isikhunta njengenye indlela yokwelapha. Umuthi wokugoma ukhunta usebenza ngokushukumisa amasosha omzimba ukuze akhiqize impendulo ethile ngokumelene nesikhunta, esinganikeza ukuvikeleka kwesikhathi eside ekuthelelekeni. Umuthi wokugoma unganikezwa abantu abasengozini ngaphambi kokuchayeka kukhunta, ukuvimbela ukutheleleka ukuthi kungenzeki kwasekuqaleni.
Ucwaningo lwakamuva olwenziwa abacwaningi baseNyuvesi yaseGeorgia lubonise amandla omgomo wokugomela i-pan-fungal ukuvikela kumagciwane amaningi esikhunta, okuhlanganisa nalawo abangela i-aspergillosis, i-candidiasis, ne-pneumocystosis. Umuthi wokugoma, obizwa nge-NXT-2, wawuklanyelwe ukuvuselela amasosha omzimba ukuze abone futhi alwe nezinhlobo ezimbalwa zesikhunta.
Ucwaningo luthole ukuthi umgomo ukwazile ukuyenga impendulo enamandla yokuzivikela komzimba kumagundane futhi ngaphezu kwalokho uwavikele ekuthelelekeni ngezifo ezihlukahlukene zesikhunta, kuhlanganise I-Aspergillus fumigatus, okuyimbangela eyinhloko ye-aspergillosis. Umuthi wokugoma utholakale uphephile futhi ubekezelelwa kahle kumagundane, nge ayikho imiphumela emibi ebikiwe.
Lolu cwaningo lukhombisa amandla omgomo we-pan-fungal ukuvikela kumagciwane amaningi okukhunta. Yize ucwaningo lungazange lubhekane ngqo nokusetshenziswa komgomo ezigulini ezinezifo ze-aspergillosis esezivele zikhona, okutholakele kusikisela ukuthi umgomo amandla okuvimbela ukutheleleka kwe-aspergillosis kubantu abasengozini enkulu.
Kafushane, ngenkathi ukwakhiwa kwemijovo yokugomela i-antifungal kunikeza enye indlela ethembisayo engase ibe khona ezinseleleni ezibangelwa izinketho zamanje zokwelapha izifo zesikhunta, ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukuphepha nokusebenza ngempumelelo komgomo kubantu, kuhlanganise nalabo abane-aspergillosis, ngaphambi kokuthi kuthathwe njengendlela yokwelashwa.
Iphepha langempela: https://academic.oup.com/pnasnexus/article/1/5/pgac248/6798391?login=false