izivikeli mzimba
Iningi labantu livikelekile ngokwemvelo ezinhlamvu ze I-Aspergillus fumigatus, noma ube namasosha omzimba anempilo ngokwanele ukuze alwe naleli gciwane. Kodwa-ke, uma une-allergic reaction (bona i-ABPA) ezinhlamvu zesikhunta kanye/noma ube nezinkinga zamaphaphu noma amasosha omzimba abuthakathaka ngakho-ke usengozini enkulu.
I-Aspergillus izinhlobo zikhiqiza izinhlamvu ezincane ezilula kakhulu futhi zintanta emoyeni osizungezile. Basakazeka kanjena. Ngokuvamile nini I-Aspergillus ezinhlamvu zihogelwa abantu, amasosha omzimba ayasebenza, izinhlamvu zibonwa njengezingaphandle futhi ziyashabalala - akukho miphumela yokutheleleka.
Kwesinye isikhathi kumuntu onamasosha omzimba abuthaka, izinhlamvu “azibonwa” futhi zingakhula ngaphakathi kwephaphu noma inxeba. Uma lokhu kwenzeka isiguli sinesifo esibizwa ngokuthi i-aspergillosis - kunezinhlobo eziningana ze-aspergillosis (imininingwane eyengeziwe).
Amasosha omzimba abuthakathaka asho ukuthi ezinye izindlela zokuzivikela ezifweni ezivame ukuvulwa lapho igciwane noma igciwane langaphandle lingena emzimbeni azisebenzi kahle - lokhu kungase kube ngenxa imiphumela emibi yokwelashwa ngamakhemikhali, noma emithini ephuzwe ngemva kwe- isitho or ukufakelwa komnwe we-bone, noma ngenxa yokuthi unesifo sofuzo esithinta amasosha omzimba njenge i-cystic fibrosis or I-CGD.
Amangqamuzana amhlophe egazi ayakwazi ukubona ingxenye yangaphandle ezicutshini zomzimba futhi ayibhubhise. An anti i-molecule ekhethekile umzimba oyikhiqizayo ukuze isize ukusebenzisa amanye amangqamuzana athile akhona ohlelweni lokuzivikela komzimba - lokhu kuyadingeka ukuze kubonwe amagciwane angaphandle njenge I-Aspergillus. Kunezinhlobo ezi-4: IgG, IgA, IgM kanye ne-IgE. Ama-antibodies ngokumelene I-Aspergillus amaprotheni angalinganiswa egazini lesiguli futhi lokhu kubonisa ukuthi isiguli singase sibe nalo I-Aspergillus ukutheleleka - lokhu kwenziwa kusetshenziswa i-enzyme-linked immunosorbent assay (ELISA), njenge-ImmunoCAP® Ukuhlolwa Kwegazi Okuqondile kwe-IgE. Okunye ukuhlolwa okulinganisa ukuthi isiguli sike sachayeka kukho yini I-Aspergillus amaprotheni abizwa ngokuthi ukuhlolwa kwe-galactomannan, lapho amasosha omzimba aqondene ne- I-Aspergillus i-cell wall molecule ihlolwa kusampula yegazi.
Esinye isilinganiso sokuthi isimiso somzimba sokuzivikela ezifweni senziwe sasebenza kanye nohlobo lokusabela okungenzeka lwenzekile, ukulinganisa amazinga e-IgE esiguli - izinga eliphakeme kakhulu liphakamisa ukusebenza kokuzivikela komzimba - khona-ke ukuba khona kwamasosha omzimba e-IgE ikakhulukazi I-Aspergillus izinhlobo zingase zihlolwe. Lokhu kuhlolwa kuzosiza ekuxilongeni okungenzeka kwe-aspergillosis.
QAPHELA kube neMihlangano Yokusekela Iziguli emibili ehlanganise izingxenye zalesi sihloko: I-IgE ne-IgG.
Yini i-IgE? Isifinyezo somuntu ongajwayelekile Qala ku-0′ 55′ 43secs
Yini i-IgG, IgM? Isifinyezo somuntu ongajwayelekile Qala ku-0′ 29′ 14secs
Amasosha omzimba kanye ne-ABPA
Uhlobo lwe-allergic I-Aspergillus ukutheleleka ngokuthi I-ABPA, okungenzeka ezigulini ezinesifuba somoya, kungatholwa ngokulinganisa izimpawu zokuzivikela komzimba ezilandelayo egazini:
- Ukwanda kwezinombolo zamaseli amhlophe, ikakhulukazi ama-eosinophil
- Ukusebenza ngokushesha kokuhlolwa kwesikhumba ukuze I-Aspergillus ama-antigens (IgE)
- Ukwandisa amasosha omzimba I-Aspergillus (IgG)
- Ingqikithi ye-IgE ephakanyisiwe
- isigqugquzeli I-Aspergillus-IgE ethile
Ingqamuzana elimhlophe legazi (eliphuzi) ligibela ibhaktheriya (iwolintshi). I-SEM yathathwa nguVolker Brinkmann: from PLoS Pathogens Vol. 1(3) Novemba 2005
Kubalulekile ukuqonda ukuthi izivivinyo eziningana zidinga ukwenziwa ukuze kunqunywe ukuthi I-Aspergillus ukutheleleka kuyimbangela yokugula kwakho, nokuthi hlobo luni lwe-aspergillosis okungenzeka ube nalo. I-Aspergillus kungase kube nzima ukuyibona futhi ngezinye izikhathi imiphumela yokuhlolwa engemihle isengasho ukuthi i-aspergillosis ayikwazi ukukhishwa. Nokho zikhona ezinye izinto eziphilayo, kokubili isikhunta kanye nebhaktheriya, ezingabangela izimpawu ezifanayo futhi kufanele ziphenywe.
I-Chronic Granulomatous Disorder (CGD)
Uma uhlushwa yilesi sifo sofuzo ungase ube sengozini I-Aspergillus izifo. Xhumana ne- Inhlangano ye-CGD ukuze uthole olunye ulwazi.