Ukukhiqizwa kwamafinyila ngokweqile kuyinkinga evamile kubantu abane-Aspergillosis ye-Allergic Bronchopulmonary (I-ABPAkanye ne-aspergillosis yamaphaphu engapheli (CPA). I-mucus iyingxube ewugqinsi yamanzi, udoti wamaselula, usawoti, lipids, namaprotheni. Idweba imigudu yethu yokuphefumula, ibambe futhi ikhiphe izinhlayiya zangaphandle emaphashini. Ugqinsi olufana nejeli lwamafinyila lubangelwa umndeni wamaphrotheni okuthiwa ama-mucins. Kubantu abaphethwe isifuba somoya, izinguquko zofuzo kulawa maprotheni e-mucin zingajiya amafinyila, kwenze kube nzima kakhulu ukuwasusa emaphashini. Lokhu kuqina kwamafinyila aminyene kuyanqwabelana futhi kungaholela ekuxhumekeni kwamafinyila, kuvimbe imigudu yokuphefumula futhi kubangele ubunzima bokuphefumula, ukuhefuzela, ukukhwehlela, nezinye izimpawu zokuphefumula.
Odokotela bavamise ukuphatha lezi zimpawu ngemithi ehogelayo njengama-bronchodilator nama-corticosteroids ukuze bavule imigudu yokuphefumula futhi banciphise ukuvuvukala. I-Mucolytics ingasetshenziswa futhi ukudiliza amapulaki e-mucus, kodwa umuthi otholakalayo kuphela, i-N-Acetylcysteine (NAC), awusebenzi kahle futhi ungabangela imiphumela emibi engadingeki. Nakuba ukwelapha kwamanje kungasiza ekulawuleni izimpawu, kunesidingo sokwelashwa okuphumelelayo nokuphephile ukuze kubhekwane ngqo nodaba lwamapulaki amafinyila.
Ukubhekana nalolu daba, kucutshungulwa izindlela ezi-3:
- I-Mucolytics yokuncibilikisa ama-plugs we-mucus
Abacwaningi eNyuvesi yaseColorado bahlola ama-mucolytics amasha njenge-tris (2-carboxyethyl) phosphine. Banikeze le mucolytic eqenjini lamagundane ane-asthmatic abhekene nokuvuvukala nokukhiqizwa kwamafinyila ngokweqile. Ngemva kokwelashwa, ukugeleza kwamafinyila kwaba ngcono, futhi amagundane aphethwe yisifuba somoya akwazi ukusula amafinyila ngokuphumelelayo njengamagundane angewona awe-asthmatic.
Kodwa-ke, ama-mucolytics asebenza ngokuphula izibopho ezibamba ama-mucins ndawonye, futhi lezi zibopho zitholakala kwamanye amaprotheni emzimbeni. Uma izibopho ziphulwa kulawa maprotheni, kungase kuholele emiphumeleni emibi engadingeki. Ngakho-ke, ucwaningo olwengeziwe luyadingeka ukuze kutholwe umuthi ozoqondisa kuphela izibopho kuma-mucins, ukunciphisa ingozi yemiphumela emibi.
2. Ukuhlanza amakristalu
Ngenye indlela, uHelen Aegerter nethimba lakhe eNyuvesi yaseBelgium bafunda amakristalu amaprotheni abakholelwa ukuthi abangela ukukhiqizwa ngokweqile kwamafinyila ku-asthma. Lawa makristalu, aziwa ngokuthi amakristalu e-Charcot-Leyden (CLC's) abangela amafinyila ukuthi ashube, ngakho-ke kube nzima ukuwasula emigwaqweni yomoya.
Ukuze libhekane namakristalu ngokuqondile, ithimba lakha amasosha omzimba ahlasela amaprotheni kumakristalu. Bahlole amasosha omzimba kumasampula amafinyila aqoqwe kubantu abanesifuba somoya. Bathole ukuthi amasosha omzimba ahlakaza ngempumelelo amakristalu ngokuzinamathisela ezifundeni ezithile zamaprotheni e-CLC awahlanganisayo. Ngaphezu kwalokho, amasosha omzimba adambise ukusabela kokuvuvukala kumagundane. Ngokusekelwe kulokhu okutholakele, abacwaningi manje basebenzela umuthi ongaba nomthelela ofanayo kubantu. U-Aegerter ukholelwa ukuthi le ndlela ingase isetshenziselwe ukwelapha izifo ezihlukahlukene ezivuthayo ezibandakanya ukukhiqizwa kwamafinyila ngokweqile, okuhlanganisa ukuvuvukala kwe-sinus kanye nokungezwani okuthile namagciwane esikhunta (njenge-ABPA).
- Ukuvimbela ukukhishwa kwe-mucus ngokweqile
Ngendlela yesithathu, isazi samaphaphu uBurton Dickey waseNyuvesi yaseTexas sisebenzela ukuvimbela amapulaki amafinyila ngokunciphisa ukukhiqizwa ngokweqile kwamafinyila. Ithimba lika-Dickey lihlonze isakhi sofuzo esithile, i-Syt2, esibandakanyeka kuphela ekukhiqizweni kwamafinyila ngokweqile hhayi ekukhiqizweni kwamafinyila okuvamile. Ukuvimbela ukukhiqizwa kwamafinyila okweqile, bakha umuthi obizwa nge-PEN-SP9-Cy ovimba isenzo sika-Syt2. Le ndlela iyathembisa ikakhulukazi njengoba ihlose ukukhiqizwa ngokweqile kwamafinyila ngaphandle kokuphazamisa imisebenzi ebalulekile yamafinyila avamile. Ukukhiqizwa kwamafinyila ajwayelekile kudlala indima ebalulekile ekuvikeleni nasekugcineni impilo yezinhlelo zokuphefumula nezokugaya ukudla. Nakuba imiphumela yokuqala ithembisa, ucwaningo olwengeziwe luyadingeka ukuze kuhlolwe ukusebenza kahle nokuphepha kwale mithi ekuhlolweni komtholampilo.
Kafushane, ama-mucus plugs aveza izimpawu ezingakhululekile ku-ABPA, CPA kanye nesifuba somoya. Ukwelashwa kwamanje kugxile ekulawulweni kwezimpawu esikhundleni sokubhekana ngqo nokunciphisa noma ukususwa kwamapulaki amafinyila. Kodwa-ke, abacwaningi bahlola izindlela ezi-3 ezingase zibe khona, ezibandakanya ama-mucolytics, ukuhlanza amakristalu, nokuvimbela ukukhishwa kwamafinyila ngokweqile. Ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe ukusebenza kahle nokuphepha kwawo, kodwa izindlela zokwenza zibonise imiphumela ethembisayo futhi esikhathini esizayo kungase kube enye indlela esingavimbela ngayo ama-mucus plug.
Ulwazi olunzulu:
I-Phlegm, amafinyila kanye nesifuba somoya | I-asthma + Lung UK