Amangqamuzana e-Airway epithelial (AECs) ayingxenye ebalulekile yesimiso sokuphefumula komuntu: Umugqa wokuqala wokuzivikela emagciwaneni asemoyeni afana ne-Aspergillus fumigatus (Af), ama-AEC adlala indima ebalulekile ekuqaliseni ukuzivikela kosokhaya nokulawula ukuphendula kwamasosha omzimba futhi abalulekile ekugcineni. impilo yokuphefumula kanye nokuvimbela izifo ezingaholela ezimweni ezifana ne-aspergillosis. Ucwaningo olwenziwa uDkt Margherita Bertuzzi waseNyuvesi yaseManchester kanye nethimba lakhe bafuna ukuqonda ukuthi ama-AEC alwa kanjani ne-Af nokuthi yini eholela ekubeni sengozini kulezi zindlela zokuzivikela, ikakhulukazi kubantu abanezimo zempilo ezicashile.
Umsebenzi wangaphambilini kaDkt Bertuzzi nethimba lakhe ubonise ukuthi ama-AEC asebenza ngempumelelo ekunqandeni ukhunta ukuthi lungalimazi lapho lusebenza kahle. Kodwa-ke, kubantu abasengozini enkulu, njengalabo abanamasosha omzimba abuthakathaka noma izimo zamaphaphu ezikhona, uma la maseli engasebenzi ngendlela efanele, isikhunta singasebenzisa lesi simo.
Lolu cwaningo olusha lukaDkt Bertuzzi nethimba lakhe luhlose ukuhlola ukuthi ama-AEC anqanda kanjani ukhunta kubantu abanempilo nokuthi yini engahambi kahle kubantu abagulayo. Ithimba labhekisisa ukusebenzisana phakathi kwesikhunta namaseli wamaphaphu avela kubantu abanempilo kanye nalabo abanezifo ezithile. Ngokusebenzisa izindlela zesayensi ezithuthukisiwe, ithimba lakwazi ukubona ukusebenzisana phakathi kwamangqamuzana amaphaphu kanye nesikhunta ezingeni elinemininingwane eminingi.
Abakutholile
Ukuhlolwa kwabonisa ukuthi isigaba sokukhula kwesikhunta sasibalulekile futhi i-carbohydrate engaphezulu - imannose (ushukela) nayo yaba nendima kule nqubo.
Ngokukhethekile, bathole ukuthi ukhunta maningi amathuba okuthi luthathwe amangqamuzana amaphaphu uma kade lukhula amahora ambalwa uma kuqhathaniswa nalapho lusasha. Izinhlamvu zesikhunta ezivuvukele ezazikhiyiwe emahoreni ama-3 kanye nayi-6 zokuhluma zafakwa kalula ngaphakathi ngokuphindwe kabili kunalezo ezikhiywe emahoreni angu-2. Baphinde bakhomba ukuthi i-molecule kashukela ebizwa ngokuthi i-mannose ebusweni besikhunta idlala indima enkulu kule nqubo.
I-Mannose iwuhlobo lwe-molecule kashukela engatholakala ebusweni bamangqamuzana ahlukahlukene, kuhlanganise nalawo amagciwane afana ne-Aspergillus fumigatus. Lo shukela udlala indima ebalulekile ekusebenzelaneni phakathi kwesikhunta namaseli omninikhaya, ikakhulukazi ama-AEC agxilise amaphaphu. Ekuphenduleni kokuzivikela komzimba okunempilo, i-mannose ebusweni be-pathogens ingabonwa ngama-mannose receptors kumaseli omzimba omzimba, okubangela uchungechunge lwezimpendulo zokuzivikela ezihloselwe ukuqeda i-pathogen. Kodwa-ke, i-Aspergillus fumigatus iye yavela ukuze isebenzise lokhu kusebenzisana, ukuyivumela ukuthi ibambelele futhi ihlasele amangqamuzana amaphaphu ngempumelelo kakhulu. Ukuba khona kwe-mannose endaweni yesikhunta kusiza ukubophezela kwayo kuma-lectins abopha mannose (MBLs) (amaprotheni abophezela ngokuqondile kumannose) ebusweni bamaseli wamaphaphu. Lokhu kubophezela kungakhuthaza ukungena ngaphakathi kwesikhunta emangqamuzaneni amaphaphu, lapho singahlala khona futhi singabangela izifo.
Ucwaningo lwagqamisa ukuthi kungenzeka ukusebenzisa lokhu kusebenzisana njengendlela yokulwa nezifo zefungal. Ngokungeza i-mannose noma ama-lectins abopha i-mannose njenge-Concanavalin A, abacwaningi banganciphisa kakhulu amandla esikhunta okuhlasela amaseli wamaphaphu. Lokhu kwehliswa kwafezwa “ngokuncintisana” nokhunta ezindaweni ezibophayo kumangqamuzana amaphaphu noma ngokuvimbela ngokuqondile i-mannose yesikhunta, ngaleyo ndlela kuvinjwe ukusebenzisana okusiza ukutheleleka kwesikhunta.
Kungani kubalulekile?
Ukuqonda lokhu kuxhumana kusinika ukuqonda okubalulekile kokuthi amaphaphu ethu asivikela kanjani ezifweni zesikhunta nokuthi yini engahambi kahle kubantu abasengozini yokuthola izifo ezinjalo. Lolu lwazi lungasiza ekwakheni izindlela zokwelapha ezintsha ezilwa namagciwane afana ne-Aspergillus fumigatus.
Ungafunda i-abstract egcwele lapha.