Entuthukweni emangalisayo ebheke ekwelapheni Izifo Ezingalapheki Obstructive Pulmonary (COPD), ososayensi, ngokokuqala ngqa, babonise amandla okulungisa izicubu zamaphaphu ezilimele besebenzisa amangqamuzana amaphaphu eziguli. Ukuphumelela kwethulwe ku-European Respiratory Society International Congress yalo nyaka eMilan, e-Italy, lapho imiphumela yokuhlolwa komtholampilo kwesigaba sokuqala kwabelwana ngakho.
I-COPD, evame kakhulu kulabo abane-chronic pulmonary aspergillosis (CPA), idala ukulimala okuqhubekayo kwezicubu zamaphaphu, kube nomthelela omkhulu empilweni yeziguli ngokuvinjwa kokuphuma komoya emaphashini. Lesi sifo, esithatha izimpilo zabantu ababalelwa ku-30,000 e-UK unyaka ngamunye, bekuyinselelo ngokomlando ukuselapha. Ukwelapha kwamanje ngokuyinhloko kugxile ekudambiseni izimpawu ngokusebenzisa ama-bronchodilator afana ne-salbutamol, anweba imigudu yomoya ukuze kuthuthukiswe ukugeleza komoya kodwa angalungisi izicubu ezilimele.
Ukufuna ukwelashwa okuqinisekile kwaholela abacwaningi ukuba bahlole izindawo ze-stem cell kanye ne-progenitor cell-based regenerative imithi. Amaseli e-stem aziwa ngokukwazi kwawo ukuguqukela kunoma yiluphi uhlobo lweseli. Ngokungafani nama-stem cell, amaseli okhokho angaphenduka abe izinhlobo ezithile zamaseli ahlobene nendawo ethile noma izicubu. Ngokwesibonelo, ingqamuzana elizalayo elisephashini lingaphenduka libe izinhlobo ezahlukene zamangqamuzana amaphaphu kodwa hhayi libe amangqamuzana enhliziyo noma amangqamuzana esibindi. Phakathi kwabacwaningi kukhona uSolwazi Wei Zuo waseTongji University, eShanghai nososayensi omkhulu kwaRegend Therapeutics. USolwazi Zuo kanye nethimba lakhe kwa-Regend bebephenya uhlobo oluthile lweseli lozalo elaziwa ngokuthi ama-P63+ lung progenitor cell.
Iziguli ze-COPD ze-20 zabhaliswa ocwaningweni, i-17 yazo yathola ukwelashwa kweseli, kanti ezintathu zisebenza njengeqembu elilawulayo. Imiphumela yayikhuthaza; ukwelashwa kwakubekezelelwa kahle, futhi iziguli zabonisa ukusebenza kwamaphaphu okuthuthukisiwe, zingahamba ngokuqhubekayo, futhi zibike izinga lempilo elingcono ngemva kokwelashwa.
Ngemva kwamasonto angu-12 alokhu kwelashwa okusha, iziguli zaba ngcono kakhulu ekusebenzeni kwamaphaphu azo. Ngokukhethekile, ikhono lamaphaphu lokudlulisa umoya-mpilo kanye ne-carbon dioxide liye futhi lisuka egazini liye lasebenza kahle kakhulu. Ukwengeza, iziguli zingahamba ziqhubeke ngesikhathi sokuhlolwa okujwayelekile okuhamba imizuzu eyisithupha. I-median (inombolo ephakathi lapho zonke izinombolo zihlelwa kusukela kwencane kakhulu kuye enkulu kunazo zonke) ibanga likhuphuke lisuka kumamitha angu-410 kuya kumamitha angu-447 - isibonakaliso esihle sokuthuthukiswa komthamo we-aerobic nokukhuthazela. Ngaphezu kwalokho, kube nokwehla okuphawulekayo kwamaphuzu avela ku-St George's Respiratory Questionnaire (SGRQ), ithuluzi elisetshenziselwa ukukala umthelela wezifo zokuphefumula kukhwalithi yokuphila iyonke. Amaphuzu aphansi abonisa ukuthi iziguli zizwe ikhwalithi yempilo yazo ithuthukile, zinezimpawu ezimbalwa nokusebenza okungcono kwansuku zonke. Sekukonke, lokhu kuphakamisa ukuthi ukwelashwa kwathuthukisa ukusebenza kwamaphaphu futhi kwaba nomthelela omuhle empilweni yansuku zonke yeziguli.
Imiphumela ye-groundbreaking iphinde yaqokomisa amandla alokhu kwelashwa ekulungiseni umonakalo wamaphaphu ezigulini ezine-emphysema encane (uhlobo lokulimala kwamaphaphu okwenzeka ku-COPD), isimo ngokuvamile esibhekwa njengesingahlehliseki futhi esiqhubekayo. Iziguli ezimbili ezibhalise ocwaningweni ezinesimo zibonise ukuxazululwa kwezilonda emasontweni angama-24 nge-CT imaging.
Kugunyazwe i-China's National Medical Products Administration (NMPA), elingana ne-UK Medicines and Healthcare products Regulatory Agency (MHRA), uvivinyo lomtholampilo lwesigaba II lusendleleni yokuhlola ukuqhubeka nokusetshenziswa kwe-P63+ progenitor cell transplantation endaweni enkulu. iqembu leziguli ze-COPD.
Lokhu okusha kungashintsha kakhulu inkambo yokwelashwa ku-COPD. USolwazi u-Omar Usmani we-Imperial College London kanye neNhloko yeqembu le-European Respiratory Society mayelana nesifo somoya, isifuba somoya, i-COPD kanye nokukhwehlela okungapheli unikeze imicabango yakhe ngokubaluleka kokuhlolwa, egcizelela isidingo esiphuthumayo sokwelashwa okuphumelelayo kwe-COPD. Waphawula ukuthi uma le miphumela iqinisekiswa ezivivinyweni ezilandelayo, kungaba impumelelo enkulu ekwelashweni kwe-COPD.
Umgwaqo ongaphambili ubonakala uthembisa, unamandla okungagcini nje ngokudambisa izimpawu eziwohlozayo ze-COPD kodwa ukulungisa umonakalo ewudalayo emaphashini, okunikeza ithemba ezigidini eziphethwe yilesi sifo sokuphefumula esingalapheki.
Ungafunda kabanzi mayelana necala lapha: https://www.ersnet.org/news-and-features/news/transplanting-patients-own-lung-cells-offers-hope-of-cure-for-copd/