Isibuyekezo esishicilelwe kamuva nje sichaza ama-antifungal amasha asendleleni enikeza ithemba ngekusasa.

Imithi emisha echazwe ekubuyekezweni inezindlela ezintsha zokusebenza zokunqoba ukumelana, futhi eminye ihlinzeka ngemithi emisha enikeza izinzuzo ezihlukile kunemithi yokwelapha yamanje ukuze kuthuthukiswe amaphrofayili okuphepha nokunciphisa ukusebenzisana. Isibonelo, i-Rezafungin ibonise umsebenzi ngokumelene I-Aspergillus futhi yehlise ubuthi besibindi, ukungena okungcono kanye nengozi encane yokungazweli.

Kuyakhuthaza kakhulu ukubona ukuthi izinhlanganisela eziningana zinomsebenzi onamandla wokulwa I-Aspergillus kanye nokuthi i-Ibrexafungerp, inhlanganisela ethinta udonga lwamaseli okukhunta, inomsebenzi omelene nabambalwa I-Aspergillus izinhlobo futhi isesigabeni sesi-3 sokuhlolwa komtholampilo.

Izinzuzo ezingaba khona zalo muthi zihlanganisa:

• Ukwakhiwa ngomlomo kanye ne-IV
• Isebenza ngokumelene nezinhlobo eziqinile
• Ukungena okungcono (IAC)
• Ukusebenzisana okuncane kwezidakamizwa nezidakamizwa

Ngaphezu kwalokho, i-olorofim, i-VL2397 ne-ABA zonke zinomsebenzi onamandla wokulwa I-Aspergillus izinhlobo futhi zisezigabeni ezihlukahlukene zokuhlolwa komtholampilo. Sekukonke, kunethemba langempela emkhathizwe