I-allergic bronchopulmonary aspergillosis (ABPA) Ngokuvamile kwenzeka ezigulini ezine-asthma noma i-cystic fibrosis. Kuncane okwaziwayo nge-ABPA ezigulini ezingenaso isifuba somoya—enesihloko esithi “ABPA sans asthma” — naphezu kokuba yaqala ukuchazwa ngawo-1980. Ucwaningo lwakamuva, olwenziwa nguDkt Valliappan Muthu kanye nozakwabo e-Postgraduate Institute of Medical Education and Research, e-Chandigarh, e-India, lubheke amarekhodi eziguli ze-ABPA ezine-asthma kanye nangenayo i-asthma, ukuze kutholwe umehluko emitholampilo phakathi kwezigaba ezimbili zezifo.

Ucwaningo lubandakanya iziguli ezingama-530, kwathi u-7% walabo abahlonzwe bene-ABPA ngaphandle kwesifuba somoya. Lolu wuphenyo olukhulu kunazo zonke olwaziwayo lwalesi sifo kuze kube manje. Kodwa-ke, njengoba ucwaningo lwenziwa ngokuphindaphindiwe esikhungweni sochwepheshe, futhi i-ABPA sans asthma yisimo esinzima ukusixilonga, inombolo yangempela yalabo abathintekayo ayaziwa.

Ukufana okuthile kwatholakala phakathi kwezinhlobo ezimbili zezifo. Kwakukhona amazinga afanayo okukhwehlela igazi (i-hemoptysis) nokukhwehlela amapulaki amafinyila. I-Bronchiectasis, isimo lapho imigudu yomoya inwetshiwe futhi ivuvukele, itholakale kaningi kulabo abangenaso isifuba somoya (97.3% vs 83.2%). Kodwa-ke, izinga amaphaphu athinteke ngalo i-bronchiectasis lalifana kuwo womabili amaqembu.

Ukuhlolwa kokusebenza kwamaphaphu (i-spirometry) babengcono kakhulu kulabo abangenaso isifuba somoya: i-spirometry evamile yatholakala ku-53.1% yalabo abangenayo isifuba somoya, uma kuqhathaniswa ne-27.7% yalabo abane-asthma. Ngaphezu kwalokho, iziguli ze-ABPA ngaphandle kwe-asthma zazincane kakhulu amathuba okuba zithole ukukhushulwa kwe-ABPA.

Ukufingqa, lolu cwaningo luthole ukuthi labo ababhekene ne-ABPA sans asthma kungenzeka babe nokusebenza okungcono kwamaphaphu kanye nokukhushulwa okumbalwa kunalabo abane-ABPA nesifuba somoya. Kodwa-ke, izimpawu zomtholampilo, njenge-mucus pugs kanye ne-haemoptysis zenzeka ngamazinga afanayo futhi i-bronchiectasis yayivame kakhulu ezigulini ze-ABPA ngaphandle kwesifuba somoya. Lesi kwakuyisifundo esikhulu kunazo zonke kuze kube manje kule subset ye-ABPA; nokho, ucwaningo olwengeziwe luyadingeka ukuze uqonde isimo kangcono.

Iphepha eligcwele: Muthu et al. (2019), Allergic bronchopulmonary aspergillosis (ABPA) ngaphandle kwesifuba somoya: I-subset ehlukile ye-ABPA enengozi encane yokwanda