Kuwedzerwa kwemucus kugadzirwa idambudziko rinowanzoitika kune vanhu vane Allergic Bronchopulmonary Aspergillosis (ABPA), uye chronic pulmonary aspergillosis (CPA) Mucus musanganiswa wakakora wemvura, marara emasero, munyu, lipids, uye mapuroteni. Inoisa mitsetse yedu yemhepo, ichiteya nekubvisa zvimedu zvekunze kubva mumapapu. Ukobvu hwakaita sejelisi hwemukoshi hunokonzerwa nemhuri yemapuroteni anonzi mucins. Muvanhu vane asima, kushanduka kwemajini kune aya mapuroteni emucin kunogona kuomesa mucus, zvichiita kuti zvinyanye kuoma kubvisa kubva mumapapu. Iyi yakakora uye yakaomeswa mucous inovaka uye inogona kutungamirira kune mucus plugs, kuvhara nzira dzemhepo uye kukonzera kunetseka kufema, kufema, kukosora, uye zvimwe zviratidzo zvekufema.
Vanachiremba vanowanzobata zviratidzo izvi nemishonga isingafemeki yakaita sebronchodilators uye corticosteroids kuvhura nzira dzemhepo uye kuderedza kuzvimba. Mucolytics inogonawo kushandiswa kuputsa mucus plugs, asi iyo chete inowanikwa mishonga, N-Acetylcysteine (NAC), hainyanyi kushanda uye inogona kukonzera zvisingadiwi migumisiro. Nepo marapirwo aripo achigona kubatsira kubata zviratidzo, panodiwa marapirwo anoshanda uye akachengeteka kugadzirisa zvakananga nyaya yemasipu plug.
Kugadzirisa dambudziko iri, 3 nzira dziri kuongororwa:
- Mucolytics yekunyungudutsa mucus plugs
Vatsvagiri paYunivhesiti yeColorado vari kuyedza mucolytics nyowani senge tris (2-carboxyethyl) phosphine. Vakapa iyi mucolytic kuboka reasthmatic mbeva dziri kusangana nekuzvimba uye kuwanda kwekugadzirwa kwemakasi. Mushure mekurapwa, kuyerera kwemakasi kwakavandudzika, uye mbeva dzeasthmatic dzaigona kubvisa mucus zvakangoita sembeva dzisiri dzeasthmatic.
Nekudaro, mucolytics inoshanda nekutyora zvisungo zvinobata mucins pamwechete, uye zvisungo izvi zvinowanikwa mune mamwe mapuroteni mumuviri. Kana zvisungo zvakaputsika mumapuroteni aya, zvinogona kutungamirira kumigumisiro isingadikanwi. Naizvozvo, kumwe kutsvagurudza kunodiwa kuti uwane mushonga unongonongedza zvisungo mumucins, kuderedza njodzi yemhedzisiro.
2. Kuchenesa makristasi
Mune imwe nzira, Helen Aegerter nechikwata chake paYunivhesiti yeBelgium vari kudzidza maprotein crystals ayo avanotenda kuti anokonzeresa kuwanda kwemakasi muasthma. Aya makristasi, anozivikanwa seCharcot-Leyden makristasi (CLC's) anoita kuti mukoshi uwedzere kukora, nekudaro kunetsa kubvisa kubva mumhepo.
Kugadzirisa makristasi zvakananga, boka rakagadzira masoja ekudzivirira chirwere anorwisa mapuroteni ari mumakristasi. Vakaedza masoja ekudzivirira chirwere pamasampunzi akatorwa kubva kuvanhu vane asthma. Vakaona kuti masoja ekudzivirira chirwere akanyungudutsa makristasi nekuzvisungirira kune chaiwo matunhu eCLC mapuroteni anoabata pamwechete. Pamusoro pezvo, masoja ekudzivirira chirwere akadzikamisa maitiro ekuzvimba mumakonzo. Kubva pane zvakawanikwa izvi, vaongorori vava kushanda pamushonga unogona kuita zvakafanana muvanhu. Aegerter anotenda kuti nzira iyi inogona kushandiswa kurapa zvirwere zvakasiyana-siyana zvinoputira zvinosanganisira kuwandisa kwemucus kugadzirwa, kusanganisira kuzvimba kwe sinus uye kumwe kusawirirana kunokonzerwa nefungal pathogens (zvakadai seABPA).
- Kudzivirira kubuda kwakanyanyisa kwemucus
Nenzira yechitatu, chiremba wepulmonologist Burton Dickey weYunivhesiti yeTexas ari kushanda kuti adzivise plugs dzemucus nekuderedza kuwandisa kwemucus. Chikwata chaDickey chakaratidza imwe gene, Syt2, inongobatanidzwa mukugadzirwa kwakawandisa kwemakasi uye kwete mukugadzirwa kwakajairika. Kuti vadzivise kugadzirwa kwemachuru akawandisa, vakagadzira mushonga unonzi PEN-SP9-Cy unovhara kuita kweSyt2. Iyi nzira inonyanya kuvimbisa sezvo inotarisa kuwandisa kwemucus pasina kupindira nemabasa akakosha emukoshi. Kugadzirwa kwemucus kwakajairika kunoita basa rakakosha mukudzivirira nekuchengetedza hutano hwekufema uye digestive system. Kunyange zvazvo migumisiro yekutanga ichivimbisa, kumwe kutsvakurudza kunodiwa kuti uongorore kushanda uye kuchengeteka kwemishonga iyi mumakiriniki ekuedzwa.
Mukupfupisa, mucus plugs anoratidza kusagadzikana zviratidzo muABPA, CPA uye asima. Kurapa kwazvino kunonangana nekutarisa zviratidzo pane kutaura zvakananga kudzikisira kana kubviswa kwemucus plugs. Zvisinei, vatsvakurudzi vari kuongorora 3 nzira dzinogona kuitika, dzinosanganisira mucolytics, kuchenesa makristasi, uye kudzivirira kuwanda kwemucus secretion. Tsvagiridzo yekuwedzera inodiwa kusimbisa kushanda kwavo uye kuchengetedzeka, asi nzira dzakaratidza mhedzisiro uye mune ramangwana inogona kuve imwe nzira yatingadzivirira mucus plugs.
Kuwedzera mamwe mashoko: