Immune system

Vanhu vazhinji havana kudzivirirwa kune spores dze Aspergillus fumigatus, kana kuva nemasoja ane hutano hwakakwana kuti arwise utachiona. Nekudaro, kana uine allergic reaction (ona ABPA) kune fungal spores uye / kana uine matambudziko emapapu kana kushaya simba immune system saka iwe unonyanya kukurumidza.

Mufananidzo wesimba rekudzivirira muviri; mufananidzo unoratidza muviri uchirwisa utachiona

Aspergillus mhando dzinogadzira tumbeu tudiki tudiki tudiki uye tunopenya mumhepo yakatitenderedza. Aya ndiwo mafambiro avanoita. Kazhinji kana Aspergillus maspores anofemerwa nevanhu, immune system yavo inogadziriswa, spores inozivikanwa seyekunze uye inoparadzwa - hapana mhedzisiro yehutachiona.
Dzimwe nguva mumunhu ane immune system isina simba, spores "haaonekwe" uye anogona kukura mukati memapapu kana ronda. Kana izvi zvaitika murwere ane chirwere chinonzi aspergillosis - kune marudzi akati wandei e aspergillosis (mamwe mashoko).

Kudzikira immune system kunoreva kuti mamwe maitiro ekudzivirira edziviriro anowanzobatidzwa kana hutachiona hwekunze kana hutachiona huchipinda mumuviri haushande nemazvo - izvi zvinogona kunge zvichikonzerwa chemotherapy, kana kumishonga inonwiwa mushure me organ or bone marrow transplant, kana kuti nekuti une chirwere chawakagarwa nhaka chinokanganisa immune system senge cystic fibrosis or CGD.

Masero machena eropa anokwanisa kuona chimwe chikamu chekunze mumatishu emuviri uye nekuchiparadza. An antibody imorekuru rakakosha rinogadzirwa nemuviri kubatsira kumisa mamwe masero ari mu immune system - izvi zvinodiwa kuti uzive hutachiona hwekunze senge. Aspergillus. Kune marudzi mana: IgG, IgA, IgM uye IgE. Masoja ekudzivirira chirwere Aspergillus mapuroteni anogona kuyerwa muropa remurwere uye izvi zvinoratidza kana murwere angave aine Aspergillus hutachiona - izvi zvinoitwa uchishandisa enzyme-yakabatana immunosorbent assay (ELISA), yakadai seImmunoCAP® Yakananga IgE Ropa Muedzo. Imwe bvunzo inoyera kana murwere akambosangana nayo Aspergillus mapuroteni anonzi the galactomannan assay, uko masoja ekudzivirira chirwere akananga kune an Aspergillus cell wall molecule inoedzwa mumuenzaniso weropa.

Chimwe chiyero chekuti immune system yakabatiswa uye inogona kukonzeresa-rudzi rwekuita yakaitika, ndeyekuyera mazinga emurwere eIgE - danho rakasimudzwa rinoratidza immune activation - ipapo kuvapo kweIgE masoja ekudzivirira chirwere. Aspergillus mhando dzinogona kuongororwa. Iyi bvunzo ichabatsira mukugoneka kuongororwa kweaspergillosis.

ONA kwave neVarwere Vatsigiro Misangano miviri yakafukidza zvikamu zvechidzidzo ichi: IgE neIgG.

Chii chinonzi IgE? Pfupiso yemunhu ari pasi Tanga pa 0′ 55′ 43secs

Chii chinonzi IgG, IgM? Pfupiso yemunhu ari pasi Tanga pa 0′ 29′ 14secs

Immune system uye ABPA

Chimiro che allergic ye Aspergillus utachiona hunonzi ABPA, iyo inogona kuitika muvarwere veasthma, inogona kuongororwa nekuyera zvinotevera immune mamaki muropa:

  • Kuwedzera machena masero, kunyanya eosinophils
  • Pakarepo ganda bvunzo reactivity kuti Aspergillus antigens (IgE)
  • Kuwedzera masoja ekudzivirira chirwere Aspergillus (IgG)
  • Yakakwira yakazara IgE
  • Yakasimudzwa Aspergillus-chaiyo IgE

Sero jena reropa (yero) rinoputira bhakitiriya (orenji). Iyo SEM yakatorwa naVolker Brinkmann: kubva kuPLoS Pathogens Vol. 1 (3) Mbudzi 2005

Zvakakosha kunzwisisa kuti bvunzo dzinoverengeka dzinoda kuitwa kuti usarudze kana Aspergillus hutachiona ndicho chikonzero chechirwere chako, uye rudzi rweaspergillosis rwaungave uine.
Aspergillus inogona kuve yakaoma kuona uye dzimwe nguva yakaipa mhedzisiro yebvunzo inogona kuramba ichireva kuti aspergillosis haigone kubviswa.
Zvisinei kune zvimwe zvipenyu, zvose fungal uye bhakitiriya, izvo zvinogona kukonzera zviratidzo zvakafanana uye zvinofanira kuongororwa.

Chronic Granulomatous Disorder (CGD)

Kana iwe uchitambura neiyo genetic disorder iwe unogona zvakare kuve panjodzi Aspergillus zvirwere. Bata ne CGD Society mamwe mashoko.

Yakapedzisira Kuvandudzwa munaNovember 1, 2020 na Megan