Clinical trials

Sarudzo yemishonga inorwisa fungal pamusika idiki, uye pane zvipimo pane izvo izvo NHS inogona kuraira. Mazhinji emhando dzefungus akashanduka kurwisa mishonga yakawanda, uye hutsinye mhedzisiro inoreva kuti vamwe varwere havagone kushivirira mamwe madhiragi, saka pane kudiwa kwakanyanya kwemaantifungal matsva, kubva kumakirasi matsva ayo asati abatwa nekuramba.

Mishonga mitsva inotenderwa sei

Kuwana mushonga mutsva ubvumidzwe inguva refu uye inodhura iyo inowanzopfuura nematanho anotevera:

Basic researchKudzidza nezvechirwere uye kutsvaga ma molecular targets emishonga mitsva yekushandisa kurwisa. 
Kuwanikwa kwezvinodhakaKuongorora maraibhurari emakemikari, kana kugadzirisa zvimiro zveanovimbisa makomisheni.
Pre-kiriniki zvidzidzoKuongorora kuti mushonga mutsva unogona kushanda zvakanaka sei muchubhu yekuyedza kana modhi yemhuka.
Chikumbiro chekutanga miedzo yevanhu
Phase 0 uye IKuongorora mushonga mune vanozvipira vane hutano, kuti vaone zvinoitika kumushonga uri mukati memuviri - kuti wakapinzwa zvakanaka sei muropa, wakagoverwa kune akakodzera tishu (semumapapu), akagadzirwa nemagetsi uye anobviswa kuburikidza neweti / tsvina. Izvi zvinobatsira vaongorori kusarudza kuti ndeapi madhasi ekushandisa mumiyedzo.
Phase IIKuedza mushonga mumazana akati wandei evarwere vane mamiriro acho, kuona kuti ndeipi dosi inonyanya kushanda uye kuwana zano repi zvakajairika mhedzisiro.
Phase IIIKuedza mushonga mumazana akati wandei kusvika kuzviuru zvevarwere vane mamiriro acho, kunyatsoyera kuti mushonga unobata sei chirwere ichi uye kuti kangani unoburitsa imwe neimwe mhedzisiro.
Chikumbiro chemvumo yezvinodhakaKunyorera kuEMA (Europe) kana kambani inodzora mishonga yakanangana nenyika yakaita seFDA (US) kuti uwane mvumo yekutanga kutengesa mushonga.
NICE wongororoKufunga kuti mushonga uyu unobatsira zvakakwana here kuti uve wakakodzera mutengo kuNHS
Kutumira / kubhadhara mariKana NICE isingakurudzire mushonga wekushandisa nguva nenguva (izvo zvave zvakadaro kune akawanda antifungals), chiremba anogona achiri kunyorera kumurwere kana CCG yemunharaunda yavo yakabvuma kuibhadhara. Iyo NAC inyanzvi yeCCG ine rusununguko rwakawedzerwa rwekutaura mamwe maantifungal, uye mamwe mayuniti ekutapurirana anogona kupa antifungal prophylaxis.
Chikamu IVIyo inozivikanwawo sepost-marketing. Kutarisa kuti mushonga unoshanda here sezvaunotarisirwa mu 'nyika chaiyo'.

Verenga zvakawanda nezve maitiro ekubvumidza: Pharmaceutical Journal or Van Norman (2016)

CCG = Clinical Commissioning Group

Sezvaunogona kufungidzira, zvakaoma kutaura uine chokwadi kuti zvichatora nguva yakareba sei kuti mishonga mitsva yaungave wakanzwa kuti iwanikwe mukiriniki. Isu tinokurukura zvichangobva kuitika mumisangano yedu yemwedzi nemwedzi yevarwere nevachengeti, izvo zvaunogona tarisai pano.

Ndeapi mishonga mitsva iri mukuedzwa kweaspergillosis?

Mishonga mitsva inowanzobvumidzwa kune invasive aspergillosis pamberi peCPA/ABPA.

  •  F901318 (olorofim) inyowani antifungal kubva kukirasi nyowani yemishonga (iyo orotomides). Iri kugadzirwa ne F2G Ltd, inova kambani inotenderera ine vanachipangamazano vanosanganisira Muzvinafundo Denning. F901318 yave kuburikidza neakasiyana Phase I miedzo uye ichangobva (Chikunguru 2018) yakapinda Phase II kutongwa kuona kuti inoshanda sei muvarwere ve100 vane invasive fungal infections vasina dzimwe nzira dzokurapa.

Maitiro ekutsvaga ruzivo nezve aspergillosis miedzo

Miedzo yemakiriniki inofanirwa kunyoreswa pachena nekuda kwezvikonzero zvehunhu (nekuti inosanganisira zvidzidzo zvevanhu). Unogona kushandisa clinicaltrials.gov kutsvaga zviedzo zvaungakodzere kutora chinhano mazviri, kana kutsvaga mibairo yemiedzo ichangopedzwa.

Kana usiri kugadzikana nenjodzi dziripo mukuyedza mushonga mutsva, unogona kuzvipira kuita registry kana diagnostics/biomarker study pane kudaro. Miedzo mizhinji inotarisa kuti tingashandise sei mishonga iripo mumiyedzo mitsva kana misanganiswa mitsva, kana mumapoka akasiyana evarwere semuenzaniso. ATCFItraconazole/voriconazole kune varwere vane cystic fibrosis vane sputum inoramba ichibatsira. Aspergillus.

screengrab yekliniki miedzo webhusaiti

Yakapedzisira Kuvandudzwa munaNovember 6, 2019 na Megan