Airway epithelial cells (AECs) chinhu chakakosha chehurongwa hwekufema kwevanhu: Mutsara wekutanga wekudzivirira kubva kune hutachiona hwemhepo hwakadai seAspergillus fumigatus (Af), maAECs anoita basa rakakosha mukutanga kudzivirira kweanoshi uye kutonga mhinduro dzemuviri uye dzakakosha mukuchengetedza. hutano hwekufema uye kudzivirira zvirwere zvinogona kutungamirira kumamiriro ezvinhu akadai seaspergillosis. Tsvagiridzo yakaitwa naDr Margherita Bertuzzi veYunivhesiti yeManchester nechikwata chake vakatsvaga kunzwisisa kuti maAEC anorwisa sei Af uye chii chinotungamira mukusagadzikana mukudzivirira uku, kunyanya muvanhu vane hutano huri pasi pasi. 

Basa rakamboitwa naDr Bertuzzi nechikwata chake rakaratidza kuti maAEC anoshanda mukumisa fungus kubva mukukuvadza kana ichishanda zvakanaka. Nekudaro, muvanhu vari panjodzi huru, sevaya vane immune system isina simba kana mamiriro emapapu aripo, kana masero aya asiri kushanda nemazvo, fungus inogona kutora mukana weiyi mamiriro.

Iyi tsvagiridzo nyowani yakaitwa naDr Bertuzzi nechikwata chake ine chinangwa chekuongorora kuti maAEC anomisa sei fungus muvanhu vane hutano uye chii chinotadza muvanhu vanorwara. Chikwata ichi chakanyatso tarisisa kudyidzana pakati pefungus nemasero emapapu kubva kune vese vane hutano uye avo vane zvimwe zvirwere. Ichishandisa nzira dzesainzi dzepamusoro, timu yakakwanisa kuona kudyidzana pakati pemasero emapapu uye fungus pamwero wakadzama.

Zvavakawana 

Ongororo dzakaratidza kuti danho rekukura kwefungal rakakosha uye carbohydrate yepasi - mannose (shuga) yaivewo nebasa mukuita.

Kunyanya, ivo vakaona kuti fungus inonyanya kutorwa nemasero emapapu kana yave kukura kwemaawa mashoma zvichienzaniswa kana ingori nyowani spore. Kuzvimba fungal spores iyo yakavharwa pa3 uye 6 maawa ekumera yaive 2-yakapetwa zviri nyore kupinda mukati kupfuura iyo yakavharwa pa0 maawa. Vakaonawo kuti shuga molecule inonzi mannose pamusoro pefungus inoita basa guru mukuita uku. 

Mannose imhando yeshuga molecule inogona kuwanikwa pamusoro pemasero akasiyana siyana, kusanganisira aya ezvirwere zvakaita seAspergillus fumigatus. Shuga iyi inoita basa rakakosha mukudyidzana pakati pefungus nemasero emuenzi, kunyanya maAEC anomisa mapapu. Mune hutano hwehutano hwekuzvidzivirira, mannose pamusoro pehutachiona hunogona kuonekwa nemannose receptors pamasero ekudzivirira muviri, zvichikonzera mutsara wemhinduro dzekudzivirira zvirwere zvinotarirwa kubvisa pathogen. Nekudaro, Aspergillus fumigatus yakashanduka kushandisa kudyidzana uku, ichiibvumira kunamatira uye kupinda mumasero emapapu zvakanyanya. Kuvapo kwemannose pamusoro pefungus 'kunofambisa kusungirirwa kwayo kune mannose-binding lectins (MBLs) (mapuroteni anosunga zvakananga kune mannose) pamusoro pemasero emapapu. Kusunga uku kunogona kukurudzira kuiswa mukati kwefungus mumasero emapapu, kwaanogona kugara uye anogona kukonzera hutachiona.

Tsvagiridzo yakaratidza mukana wekushandisa kudyidzana uku senzira yekurwisa hutachiona hwefungal. Nekuwedzera mannose kana mannose-binding lectins seConcanavalin A, vaongorori vanogona kuderedza zvakanyanya kugona kwefungus kupinda mumasero emapapu. Uku kudzikiswa kwakaitwa nekunyanya "kukwikwidzana" nefungus yenzvimbo dzinosunga pamasero emapapu kana nekuvharira zvakananga fungal mannose, nekudaro kuvharidzira kusangana kunobatsira hutachiona hwefungal.

Nei zvichikosha?

Kunzwisisa kudyidzana uku kunotipa ruzivo rwakakosha rwekuti mapapu edu anotidzivirira sei kubva kuhosha dzefungal uye chii chinokanganisa muvanhu vari panjodzi yezvirwere zvakadaro. Ruzivo urwu runogona kubatsira mukugadzira mishonga mitsva yekurwisa utachiona seAspergillus fumigatus.

Unogona kuverenga chidimbu chakazara pano.