Mukufambira mberi kunoshamisa mukurapa Chronic Obstructive Pulmonary Disease (COPD), masayendisiti, kekutanga, aratidza kugona kwekugadzirisa mapapu akakuvadzwa matishu achishandisa masero emapapu evarwere. Kubudirira uku kwakaparurwa paEuropean Respiratory Society International Congress yegore rino muMilan, Italy, uko zvakabuda muchikamu chekutanga chekuyedza kiriniki zvakagoverwa.

COPD, iyo inowanzoitika kune avo vane chronic pulmonary aspergillosis (CPA), inokonzera kukanganisa kunofambira mberi kumapapu emapapu, zvichinyanya kukanganisa hupenyu hwevarwere kuburikidza nekuvharwa kwemhepo kubva mumapapu. Chirwere ichi, chinotora hupenyu hwevanhu vanosvika zviuru makumi matatu muUK gore rega rega, chave chichinetsa kurapa. Mishonga yemazuva ano inonyanya kutarisa kuderedza zviratidzo kuburikidza nebronchodilators se salbutamol, iyo inowedzera nzira dzemhepo kuti iwedzere kuyerera kwemhepo asi haigadzirise nyama yakakanganisika.

Kutsvaga kurapwa kwakanyanya kwakatungamira vaongorori kuti vaongorore nzvimbo dze stem cell uye progenitor cell-based regenerative mushonga. Stem masero anozivikanwa nekugona kwavo kuita morph mune chero sero rudzi. Kusiyana ne stem maseru, maseru eprogenitor anogona kungoshanduka kuita mamwe marudzi emasero ane hukama nenzvimbo yakati kana matishu. Semuenzaniso, sero remukati mumapapu rinogona kushanduka kuita marudzi akasiyana emasero emapapu asi kwete kuita maseru emwoyo kana masero echiropa. Pakati pevaongorori ndiProfessor Wei Zuo anobva kuTongji University, Shanghai uye sainzi mukuru kuRegend Therapeutics. Muzvinafundo Zuo nechikwata chake kuRegend vanga vachiferefeta rudzi rwakati rwesero rinozivikanwa seP63+ lung progenitor cells.

Chikamu chekutanga chekuyedza kiriniki chakatangwa naProfessor Zuo nevamwe vake chaive nechinangwa chekuongorora kuchengetedzeka uye kushanda nesimba kwekubvisa P63+ masero ekutanga kubva mumapapu evarwere, vozoawedzera mumamiriyoni avo murabhoritari vasati vaaisa mumapapu avo.

20 COPD varwere vakanyoreswa mukutongwa, 17 avo vakagamuchira kurapwa kwesero, asi vatatu vakashanda seboka rinodzora. Migumisiro yacho yaikurudzira; kurapwa kwakanyatso kushivirirwa, uye varwere vakaratidza kuvandudza kushanda kwemapapu, vaigona kufamba mberi, uye vakashuma hupenyu huri nani hunotevera kurapwa.

Mushure memavhiki gumi nemaviri ekurapa kutsva uku, varwere vakawana kuvandudzwa kwakakosha mukushanda kwemapapu avo. Kunyanya, kugona kwemapapu ekufambisa okisijeni nekabhoni dhayokisaidhi kuenda nekubva muropa kwakawedzera kushanda. Pamusoro pezvo, varwere vaigona kufamba mberi panguva yekuyedzwa kwemaminetsi matanhatu ekufamba. Pakati (nhamba yepakati apo nhamba dzose dzakarongwa kubva padiki kusvika pakukura) kureba kwakawedzera kubva pamamita 12 kusvika ku 410 mamita - chiratidzo chakanaka chekuvandudzwa kwe aerobic simba uye kutsungirira. Zvakare, pakave nekudzikira kunoshamisa kwezvibodzwa kubva kuSt George's Respiratory Questionnaire (SGRQ), chishandiso chinoshandiswa kuyera kukanganisa kwezvirwere zvekufema pamhando yehupenyu hwese. Chibodzwa chakaderera chinoratidza kuti varwere vainzwa hupenyu hwavo hwave nani, vaine zviratidzo zvishoma uye kushanda kuri nani zuva nezuva. Pakazara, izvi zvinoratidza kuti kurapwa kwakavandudza mapapu uye kwakakanganisa hupenyu hwezuva nezuva hwevarwere.

Mhedzisiro inoparadza yakaratidzawo kugona kwekurapa uku mukugadzirisa kukuvadzwa kwemapapu muvarwere vane emphysema yakapfava (rudzi rwekukuvara kwemapapu kunoitika muCOPD), mamiriro anowanzoonekwa seasingadzoreki uye anofambira mberi. Varwere vaviri vakanyoresa pakutongwa nemamiriro ezvinhu vakaratidza kugadziriswa kwezvipembenene pamasvondo e24 neCT imaging. 

Yakatsigirwa neChina's National Medical Products Administration (NMPA), iyo yakaenzana neUK Medicines and Healthcare products Regulatory Agency (MHRA), chikamu chechipiri chekiriniki yekuedza chiri mupombi yekuyedza kuwedzera kushandiswa kweP63+ progenitor cell transplantation mune yakakura. boka revarwere veCOPD. 

Ichi chitsva chinogona kuchinja zvakanyanya nzira yekurapa muCOPD. Muzvinafundo Omar Usmani weImperial College London uye Musoro weboka reEuropean Respiratory Society pamusoro pechirwere chemhepo, asima, COPD uye chikosoro chisingaperi vakapa pfungwa dzake pamusoro pekukosha kwemuyedzo, zvichisimbisa kudiwa kwekukurumidzira kwekurapa kunoshanda kweCOPD. Akataura kuti kana mhedzisiro iyi ikasimbiswa mune inotevera miedzo, ingave budiriro huru mukurapa kweCOPD.

Mugwagwa uri kumberi unoratidzika kunge uchivimbisa, uine mukana wekuti usangorerutsa zviratidzo zveCOPD asi kugadzirisa kukuvadzwa kwazvinoita pamapapu, zvichipa tariro kumamirioni ari kurwara nechirwere ichi chisingaperi chekufema.

Unogona kuverenga zvakadzama nezve kutongwa pano: https://www.ersnet.org/news-and-features/news/transplanting-patients-own-lung-cells-offers-hope-of-cure-for-copd/