Huwandu hwevanhu vari panjodzi yekutapukirwa nefungal huri kuwedzera nekuda kwehuwandu hwekuchembera, kuwedzera kushandiswa kwemishonga inodzivirira muviri, mamiriro ezvehutano agara aripo, shanduko yezvakatipoteredza, uye mararamiro ehupenyu. Naizvozvo, pane kudiwa kuri kukura kwemishonga mitsva kana nzira dzekudzivirira.

Ikozvino nzira dzekurapa kwehutachiona hwefungal dzinowanzobatanidza kushandiswa kwemishonga inorwisa fungal, yakadai seazoles, echinocandins, uye polyenes. Mishonga iyi inowanzo shanda mukurapa fungal utachiona, asi inogona kuve nekukanganisa. Semuenzaniso, mamwe antifungal zvinodhaka anogona kudyidzana nemimwe mishonga, zvichitungamira kune zvinogona kukuvadza mhedzisiro. Pamusoro pezvo, kushandiswa zvakanyanya kwemishonga inorwisa fungal kunogona kubatsira mukuvandudza kweantifungal zvinodhaka kuramba, izvo zvinogona kuita kuti kurapwa kuve kwakaoma.

Pave nekufarira kuri kuramba kuchikura mukugadzirwa kwemajekiseni efungal seimwe nzira yekurapa. A fungal vaccine inoshanda nekukurudzira immune system kuti ibudise mhinduro chaiyo kurwisa fungus, iyo inogona kupa kudzivirirwa kwenguva refu kubva kuhutachiona. Mushonga uyu unogona kupihwa kune vanhu vari panjodzi vasati vasangana nefungus, kudzivirira hutachiona kubva pakutanga.

Ongororo ichangoburwa nevanoongorora kubva kuYunivhesiti yeGeorgia yakaratidza mukana wepan-fungal vaccine kudzivirira kubva kune akawanda fungal pathogens, kusanganisira ayo anokonzera. aspergillosis, candidiasis, uye pneumocystosis. Mushonga uyu, unonzi NXT-2, wakagadzirirwa kukurudzira immune system kuti izive uye kurwisa marudzi akati wandei efungi.

Ongororo yakawana kuti jekiseni rakakwanisa kupinza mhinduro yakasimba yekudzivirira muviri mumakonzo uye nekuwedzera kuvadzivirira kubva kuhutachiona nemhando dzakasiyana dzefungal pathogens, kusanganisira Aspergillus fumigatus, iyo ndiyo inonyanya kukonzera aspergillosis. Mushonga wacho wakawanikwa wakachengeteka uye wakabvumirwa zvakanaka mumakonzo, ne hapana mhedzisiro yakaipa yakataurwa.

Chidzidzo ichi chinoratidza kugona kwemushonga wepan-fungal wekudzivirira kubva kune dzakawanda fungal pathogens. Kunyange chidzidzo ichi chisina kunyatsogadzirisa kushandiswa kwejekiseni muvarwere vane pre-existing aspergillosis utachiona, zvakawanikwa zvinoratidza kuti jekiseni rine mukana wekudzivirira hutachiona hweaspergillosis muvanhu vane njodzi yakanyanya.

Muchidimbu, nepo kugadzirwa kwemajekiseni ekudzivirira fungal kunopa inovimbisa imwe nzira kune zvipingamupinyi zvinounzwa neazvino kurapwa sarudzo dzehutachiona hwefungal, kumwe kutsvagurudza kunodiwa kuona kuchengetedzeka uye kushanda kwejekiseni muvanhu, kusanganisira avo vane aspergillosis, isati yagona. kutorwa senzira yekurapa.

Pepa rekutanga: https://academic.oup.com/pnasnexus/article/1/5/pgac248/6798391?login=false