Amanani abantu abasemngciphekweni wosulelo lomngundo ayanda ngenxa yokuguga kwabantu, ukwanda kokusetyenziswa kwamayeza e-immunosuppressive, iimeko zonyango esele zikhona, utshintsho lwemo engqongileyo, kunye neendlela zokuphila. Ke ngoko, kukho imfuneko ekhulayo yonyango olutsha okanye iindlela zokuthintela.
Ukhetho lwangoku lonyango lwezifo zefungal luhlala lubandakanya ukusetyenziswa kwamayeza e-antifungal, njenge-azoles, i-echinocandins, kunye ne-polyenes. La mayeza asebenza ngokubanzi ekunyangeni usulelo lomngundo, kodwa anokuba nemiqobo. Ngokomzekelo, amanye amachiza e-antifungal anokunxibelelana namanye amayeza, okukhokelela kwimiphumo enokuba yingozi. Ukongezelela, ukusetyenziswa ngokugqithiseleyo kwamachiza e-antifungal kunokufak' isandla ekuphuhliseni ukuxhathisa amayeza e-antifungal, nto leyo enokwenza unyango lube nzima ngakumbi.
Kubekho umdla okhulayo kuphuhliso lwezitofu zokungunda njengolunye unyango. Isitofu sokugonya sefungal sisebenza ngokuvuselela amajoni omzimba ukuvelisa impendulo ethile ngokuchasene nefungus, enokubonelela ngokukhuselwa kwexesha elide kwintsholongwane. Isitofu sokugonya sinokunikwa abantu abasemngciphekweni phambi kokuba sesichengeni sokungunda, ukuthintela usulelo ukuba lwenzeke kwasekuqaleni.
Uphononongo lwakutsha nje olwenziwa ngabaphandi abavela kwiDyunivesithi yaseGeorgia lubonise ukubanakho ukugonya kwe-pan-fungal ukukhusela kwiintsholongwane ezininzi zefungal, kubandakanya nezo zibangela. aspergillosis, candidiasis kunye pneumocystosis. Isitofu sokugonya, esibizwa ngokuba yi-NXT-2, sasiyilelwe ukuvuselela amajoni omzimba ukuba aqaphele kwaye alwe neendidi ezininzi zomngundo.
Uphononongo lufumanise ukuba isitofu sokugonya sikwazile ukukhuthaza impendulo enamandla omzimba kwiimpuku kwaye ukongezelela ukubakhusela kusulelo kunye neentsholongwane ezininzi ezahlukeneyo zokungunda, kubandakanya I-Aspergillus fumigatus, eyona nto ibangela i-aspergillosis. Isitofu sokugonya sifunyenwe sikhuselekile kwaye sinyamezeleke kakuhle kwiimpuku, nge akukho ziphumo zibi zichaziweyo.
Olu phononongo lubonisa ukubanakho kwesitofu sokungunda esinokubakho ukukhusela kwiintsholongwane zokungunda ezininzi. Ngelixa uphononongo lungakhange lujongane ngokuthe ngqo nokusetyenziswa kwesitofu sokugonya kwizigulana ezinosulelo lwe-aspergillosis esele lukhona, iziphumo zibonisa ukuba isitofu sokugonya sinalo. ukuthintela usulelo lwe-aspergillosis kubantu abasengozini enkulu.
Isishwankathelo, ngelixa uphuhliso lwezitofu zokugonya i-antifungal lubonelela ngenye indlela ethembisayo kwimingeni ebangelwa lukhetho lwangoku lonyango losulelo lomngundo, uphando olongezelelweyo luyafuneka ukuze kuqinisekiswe ukhuseleko kunye nokusebenza kwesitofu sokugonya ebantwini, kubandakanya abo bane-aspergillosis, ngaphambi kokuba ikwazi. kuthathwa njengokhetho lonyango.
Iphepha lokuqala: https://academic.oup.com/pnasnexus/article/1/5/pgac248/6798391?login=false