Inkqubo yomzimba
Uninzi lwabantu lukhuselekile ngokwendalo kwimbewu ye I-Aspergillus fumigatus, okanye ube nesistim somzimba esisempilweni ngokwaneleyo sokulwa nosulelo. Nangona kunjalo, ukuba une-allergic reaction (bona i-ABPA) ukuya kwintsholongwane yomngundo kunye/okanye uneengxaki zemiphunga okanye amajoni omzimba abuthathaka ngoko uchaphazeleka ngakumbi.
I-Aspergillus iintlobo zezityalo zivelisa imikroskopu emincinci ekhula ngokugqithisileyo kwaye idada emoyeni osingqongileyo. Basasazeka ngolo hlobo. Ngokuqhelekileyo xa I-Aspergillus Imbewu itsalwa ngabantu, amajoni abo omzimba ayasebenza, iimbewu zibonwa njengezangaphandle kwaye ziyatshatyalaliswa - akukho ziphumo zosulelo.
Ngamanye amaxesha kumntu obuthathaka amajoni omzimba “azibonwa” kwaye zinokukhula ngaphakathi kwimiphunga okanye inxeba. Xa oku kusenzeka isigulana sinesigulo esibizwa ngokuba yi-aspergillosis – kukho iindidi ezininzi ezahlukeneyo ze-aspergillosis (i-aspergillosis)ezinye iinkcukacha).
Isistim somzimba esibuthathaka sithetha ukuba ezinye iimpendulo zokhuselo lomzimba ezidla ngokuvulwa xa intsholongwane yangaphandle okanye intsholongwane ingena emzimbeni ayisebenzi ngokufanelekileyo- oku kunokubangwa chemotherapy, okanye kumayeza athathwe emva kwe ilungu or ukutsalwa komongo wethambo, okanye ngenxa yokuba unesifo sofuzo esichaphazela amajoni omzimba njenge icystic fibrosis or I-cgd.
Iiseli ezimhlophe zegazi ziyakwazi ukuqaphela icandelo langaphandle kwizicubu zomzimba kwaye zitshabalalise. An anti yimolekyuli ekhethekileyo eveliswa ngumzimba ukunceda ukusebenzisa ezinye zeeseli ezithile ezikhoyo kukhuselo lomzimba- oku kuyafuneka ukuze kubonwe intsholongwane yangaphandle efana I-Aspergillus. Kukho iindidi ezi-4: IgG, IgA, IgM kunye ne-IgE. Amajoni achaseneyo I-Aspergillus Iiproteni zinokulinganiswa egazini lesigulana kwaye oku kubonisa ukuba isigulana sinokuba nalo I-Aspergillus usulelo - oku kwenziwa kusetyenziswa i-enzyme-linked immunosorbent assay (ELISA), njenge-ImmunoCAP® Uvavanyo lweGazi lwe-IgE oluthe ngqo. Olunye uvavanyo olulinganisa ukuba isigulana sikhe sachatshazelwa na I-Aspergillus Iiproteni zibizwa ngokuba yi uvavanyo lwegalactomannan, apho izilwa-buhlungu ezikhethekileyo kwi- I-Aspergillus imolekyuli yodonga lweseli ivavanywa kwisampulu yegazi.
Omnye umlinganiselo wokuba umxokomezelo wokhuselo lomzimba uyasebenza kwaye uhlobo lokusabela olunokubakho lwenzekile, kukulinganisa amanqanaba e-IgE yesigulana-inqanaba elinyuswe kakhulu libonisa ukuba kusebenze amajoni omzimba- emva koko ubukho be-IgE antibodies ngokukodwa I-Aspergillus iintlobo zinokuvavanywa. Olu vavanyo luya kunceda ukuxilongwa okunokwenzeka kwe-aspergillosis.
QAPHELA kukho iiNtlanganiso ezimbini zokuXhasa iziGulane eziye zagubungela iinxalenye zalo mbandela: IgE kunye ne-IgG.
Yintoni i-IgE? Isishwankathelo sommangalelwa Qala ku-0′ 55′ 43secs
Yintoni i-IgG, IgM? Isishwankathelo sommangalelwa Qala ku-0′ 29′ 14secs
Inkqubo yamajoni omzimba kunye ne-ABPA
Uhlobo lwe-allergic I-Aspergillus usulelo olubizwayo ABPA, enokuthi yenzeke kwizigulana ze-asthma, inokufunyaniswa ngokulinganisa ezi mpawu zilandelayo ze-immune egazini:
- Ukunyuka kwamanani eeseli ezimhlophe, ngakumbi ii-eosinophils
- Uvavanyo lwesikhumba olukhawulezileyo reactivity ukuya I-Aspergillus iiantigens (IgE)
- Ukunyusa amajoni omzimba ukuba I-Aspergillus (I-IGG)
- Iyonke i-IgE ephakanyisiweyo
- liphakanyiswe I-Aspergillus-IgE ethile
Iseli emhlophe yegazi (etyheli) iginya ibhaktiriya (orenji). I-SEM yathathwa nguVolker Brinkmann: ukusuka kwiPLoS Pathogens Vol. 1(3) Novemba 2005
Kubalulekile ukuqonda ukuba iimvavanyo ezininzi kufuneka zenziwe ukuze kuthathwe isigqibo sokuba ngaba I-Aspergillus usulelo ngunobangela wokugula kwakho, kwaye loluphi uhlobo lwe-aspergillosis onokuba nalo. I-Aspergillus kunokuba nzima ukubhaqa kwaye ngamanye amaxesha iziphumo zovavanyo ezingalunganga zisenokuthetha ukuba i-aspergillosis ayinakukhutshelwa ngaphandle. Nangona kunjalo kukho ezinye izinto eziphilayo, zombini umngundo kunye neebhaktheriya, ezinokubangela iimpawu ezifanayo kwaye kufuneka ziphandwe.
Isifo seGranulomatous esingapheliyo (CGD)
Ukuba unengxaki yolu hlobo lwemfuza nawe usenokuba sesichengeni I-Aspergillus usulelo. Qhagamshelana ne Umbutho weCGD ufuna ulwazi olungolunye.