Iiseli ze-Airway epithelial (AECs) ziyinxalenye ephambili yenkqubo yokuphefumla komntu: Umgca wokuqala wokukhusela kwiintsholongwane zomoya ezifana ne-Aspergillus fumigatus (Af), ii-AECs zidlala indima ebalulekileyo ekuqaliseni ukukhusela umkhosi kunye nokulawula iimpendulo ze-immune kwaye zibalulekile ekugcineni impilo yokuphefumula kunye nokuthintela usulelo olunokukhokelela kwiimeko ezifana ne-aspergillosis. Uphando olwenziwe nguGqr Margherita Bertuzzi weYunivesithi yaseManchester kunye neqela lakhe baye bazama ukuqonda ukuba ii-AECs zilwa njani ne-Af kunye nokuba yintoni ekhokelela ekubeni ube sesichengeni kolu khuselo, ngakumbi kubantu abaneemeko zempilo eziphantsi.
Umsebenzi wangaphambili owenziwe nguGqr Bertuzzi kunye neqela lakhe ubonise ukuba ii-AECs ziyasebenza ekunqandeni ukungunda ekwenzeni ingozi xa zisebenza kakuhle. Nangona kunjalo, kubantu abasemngciphekweni omkhulu, njengabo babuthathaka amajoni omzimba okanye iimeko zemiphunga ezikhoyo, ukuba ezi seli zingasebenzi ngokuchanekileyo, i-fungus inokusebenzisa le meko.
Olu phando olutsha olwenziwa nguGqr Bertuzzi kunye neqela lakhe lijolise ekuphononongeni indlela i-AECs eyeka ngayo i-fungus kubantu abaphilileyo kunye noko kungahambi kakuhle kubantu abagulayo. Iqela lijonge ngononophelo intsebenziswano phakathi kwefungus kunye neeseli zemiphunga ezivela kubantu abasempilweni kunye nabo banezifo ezithile. Ukusebenzisa iindlela eziphambili zenzululwazi, iqela liye lakwazi ukujonga intsebenziswano phakathi kweeseli zemiphunga kunye nefungus kwinqanaba elineenkcukacha kakhulu.
Oko Bakufumeneyo
Iimvavanyo zibonise ukuba inqanaba lokukhula kwefungal lalibalulekile kwaye i-carbohydrate engaphezulu - imannose (iswekile) nayo yayinendima kwinkqubo.
Ngokukodwa, bafumanise ukuba i-fungus inokuthi ithathwe ziiseli zemiphunga xa sele ikhula iiyure ezimbalwa xa ithelekiswa naxa isispore nje esitsha. Iintsholongwane zokungunda ezidumbileyo ezivaliweyo kwi-3 kunye neeyure ze-6 zokuntshula ziphindwe kabini ngokukhawuleza zifakwe ngaphakathi kunezo zitshixiwe kwiiyure ze-2. Bachonge kwakhona ukuba imolekyuli yeswekile ebizwa ngokuba yimannose kumphezulu wefungus idlala indima enkulu kule nkqubo.
Imannose luhlobo lwemolekyuli yeswekile enokufumaneka kumphezulu weeseli ezahlukeneyo, kubandakanywa nezo zezifo ezifana neAspergillus fumigatus. Le swekile idlala indima ebalulekileyo kwintsebenziswano phakathi kwefungus kunye neeseli zomkhosi, ngakumbi ii-AECs ezihlala emiphunga. Kwimpendulo ye-immune enempilo, i-mannose ebusweni be-pathogens inokuqatshelwa ngama-receptors e-mannose kwiiseli ze-immune, ezibangela uchungechunge lweempendulo ze-immune ezijoliswe ekupheliseni i-pathogen. Nangona kunjalo, i-Aspergillus fumigatus iye yavela ukuze isebenzise oku kusebenzisana, ukuyivumela ukuba ibambelele kwaye ihlasele iiseli zemiphunga ngempumelelo ngakumbi. Ubukho bemannose kumphezulu womngundo buququzelela ukubophelela kwayo kwimannose-binding lectins (MBLs) (iiproteni ezibophelela ngokukodwa kwimannose) kumphezulu weeseli zemiphunga. Oku kubopha kunokukhuthaza ukufakwa ngaphakathi kwefungus kwiiseli zemiphunga, apho inokuhlala khona kwaye inokubangela usulelo.
Uphando luqaqambise ukuba nokwenzeka kokulawula olu nxibelelwano njengendlela yokulwa nosulelo lomngundo. Ngokudibanisa imannose okanye iilectin ezibopha imannose njengeConcanavalin A, abaphandi banokunciphisa kakhulu amandla efungus okuhlasela iiseli zemiphunga. Oku kuncitshiswa kwafezwa ngokubalulekileyo "ukukhuphisana" kunye nefungus kwiindawo ezibophelelayo kwiiseli zemiphunga okanye ngokuthintela ngokuthe ngqo i-mannose yefungal, ngaloo ndlela inqanda ukusebenzisana okuququzelela ukusuleleka kwefungal.
Kutheni kubalulekile?
Ukuqonda olu nxibelelwano kusinika ukuqonda okubalulekileyo kwindlela imiphunga yethu isikhusela ngayo kusulelo lomngundo kwaye yintoni engahambi kakuhle kubantu abasesichengeni sosulelo olunjalo. Olu lwazi lunokunceda ekudaleni unyango olutsha oluchasene ne-pathogens efana ne-Aspergillus fumigatus.
Unokufunda i-abstract epheleleyo Apha.