Ukunyanga i-aspergillosis, kule meko, i-aspergillosis eyingozi, kunye neyeza elichasayo linemida yalo. Zithanda ukuba yityhefu kwaye kufuneka zisetyenziswe ngononophelo ngoogqirha abanamava. Xa unyangwa kakhulu umntu immunocompromised wosulelwe I-Aspergillus (elelona qela liphambili labantu abafumana uhlobo oluyingozi lwesi sifo) amazinga okusweleka angadlula ama-50% kumaqela ezigulana anyangwa i-leukemia. Kulula ukubona ukuba kufuneka siphuhlise unyango olungcono kunye neendlela ezahlukeneyo zonyango.

Iqela lophando laseJamani kwiYunivesithi yaseWurtzburg, elikhokelwa nguJurgan Loffler kunye noMichael Hudacek baye bamkela indlela eyahlukileyo ngokupheleleyo yokunyanga i-aspergillosis, endaweni yokuphuhlisa amayeza e-antifungal baye bakhetha 'ukuqeqesha' amajoni omzimba kwizigulana ezigogekileyo ukuba ziqaphele kwaye zihlasele. usulelo ngcono ngethemba lokuba oku kuyakuphucula ukusweleka.

Le teknoloji ikhutshelwe kuphando lomhlaza, apho siyazi ukuba ezinye ii-cancer zibalekela uhlaselo lwe-immune system kwaye oku kuvumela ukuba umhlaza ukhule. Abaphandi banjalo ngempumelelo 'ukuqeqesha kwakhona' amajoni omzimba omkhosi ukuhlasela iiseli zomhlaza ngempumelelo ngakumbi.

Iqela lathatha iiseli ukusuka kumajoni omzimba wempuku (T-cells) ezidla ngokuhlasela iintsholongwane ezosulelayo ukuze ziphelise usulelo kwaye zonyuse amandla azo okufumana. I-Aspergillus fumigatus, eyona pathogen iphambili eyenza i-aspergillosis. Ezi seli zanikwa iimpuku ezosulelwe zizo I-Aspergillus inkqubo yemodeli yemouse ejoliswe ukulinganisa i-aspergillosis eyingozi kwizigulane zabantu.

Isiphumo sesokuba kwezompuku zine-aspergillosis ye-pulmonary invasive kwaye zingenalo unyango, i-33% yahlala iphila ngelixa ezo iimpuku zaye zanyangwa nge-booster T-cells (CAR-T) i-80% yasinda.

Esi siphumo sibonisa isithembiso esikhulu sonyango lwe-aspergillosis. Ezi ziphumo zovavanyo kufuneka ziphindaphindwe kumkhosi womntu kodwa kuyacaca ukuba le ndlela inokwenza isiseko sendlela entsha ngokupheleleyo yokunyanga i-aspergillosis, kubandakanywa neendlela ezingapheliyo ze-aspergillosis ezifana ne-chronic pulmonary aspergillosis (CPA) kwaye mhlawumbi ne-bronchopulmonary i-aspergillosis (ABPA).

Iphepha elipheleleyo lipapashwe apha