Kwinkqubela phambili ebalaseleyo ebhekiselele kunyango lweSifo esiNganyangekiyo sePulmonary (COPD), izazinzulu, okokuqala ngqa, zibonise amandla okulungisa izihlunu zemiphunga ezonakeleyo zisebenzisa iiseli zemiphunga yezigulana. Ukuphumelela kuye kwatyhilwa kwiNkongolo yaMazwe ngaMazwe ye-European Respiratory Society eMilan, e-Italiya, apho iziphumo zolingo lwezonyango lwesigaba sokuqala kwabelwana ngazo.
I-COPD, eqhelekileyo kwabo bane-chronic pulmonary aspergillosis (CPA), ibangela umonakalo oqhubekayo kwizicubu zemiphunga, ichaphazela kakhulu umgangatho wobomi bezigulana ngokuphazamiseka kokuphuma komoya emiphungeni. Esi sifo, esibanga ubomi babantu abamalunga nama-30,000 e-UK nyaka ngamnye, bekunzima ukusinyanga ngokwembali. Unyango lwangoku lugxininise kakhulu ekunciphiseni iimpawu ngokusebenzisa i-bronchodilators ezifana ne-salbutamol, eyandisa i-airways ukuphucula ukuhamba komoya kodwa ingalungisi izicubu ezonakalisiweyo.
Ukukhangela unyango oluqinisekileyo ngakumbi lukhokelele abaphandi ukuba baphonononge iindawo ze-stem cell kunye neyeza le-progenitor cell-based regenerative. Iiseli ze-Stem zaziwa ngokukwazi kwazo ukwenza i-morph kulo naluphi na uhlobo lweeseli. Ngokungafaniyo neeseli ze-stem, iiseli ze-progenitor zinokujika zibe ziintlobo ezithile zeeseli ezinxulumene nommandla othile okanye izicubu. Umzekelo, iseli yomzali emiphungeni inokujika ibe ziintlobo ezahlukeneyo zeeseli zemiphunga kodwa ingabi kwiiseli zentliziyo okanye iiseli zesibindi. Phakathi kwabaphandi nguNjingalwazi Wei Zuo ovela kwiYunivesithi yaseTongji, eShanghai kunye nososayensi oyintloko kwiRegend Therapeutics. Unjingalwazi uZuo kunye neqela lakhe e-Regend bebephanda uhlobo oluthile lweeseli ze-progenitor ezaziwa ngokuba ziiseli ze-lung progenitor P63+.
Izigulane ze-20 ze-COPD zabhaliswa kulingo, i-17 yazo yafumana unyango lweseli, ngelixa ezintathu zisebenza njengeqela lokulawula. Iziphumo zazikhuthaza; unyango lunyanyezelwe kakuhle, kwaye izigulane zibonise ukusebenza okuphuculweyo kwemiphunga, zinokuhamba ngakumbi, kwaye zichaze umgangatho ongcono wobomi obulandela unyango.
Emva kweeveki ezili-12 zolu nyango lutsha, izigulane ziye zafumana ukuphucuka okubonakalayo ekusebenzeni kwemiphunga yazo. Ngokukodwa, ukukwazi kwemiphunga ukuhambisa ioksijini kunye nekharbon diokside ukuya kunye nokuphuma kwegazi kuye kwasebenza ngakumbi. Ukongeza, izigulane zinokuhamba ngakumbi ngexesha lovavanyo oluqhelekileyo lwemizuzu emithandathu. I-median (inani eliphakathi xa onke amanani acwangciswa ukusuka kwincinci ukuya kwenkulu) umgama unyukile ukusuka kwi-410 yeemitha ukuya kwi-447 yeemitha - uphawu oluhle lokuphucula umthamo we-aerobic kunye nokunyamezela. Ngaphezu koko, kukho ukuhla okuphawulekayo kumanqaku avela kwi-St George's Respiratory Questionnaire (SGRQ), isixhobo esisetyenziselwa ukulinganisa impembelelo yezifo zokuphefumula kumgangatho wobomi bonke. Amanqaku asezantsi abonisa ukuba izigulana zivakalelwa kukuba umgangatho wobomi uphucukile, zineempawu ezimbalwa kunye nokusebenza okungcono kwemihla ngemihla. Lilonke, oku kuphakamisa ukuba unyango luphucule ukusebenza kwemiphunga kwaye lwaba nefuthe elihle kubomi bemihla ngemihla bezigulane.
Iziphumo ze-groundbreaking ziphinde zabonisa ukubanakho kolu nyango ekulungiseni umonakalo wemiphunga kwizigulana ezine-emphysema epholileyo (uhlobo lomonakalo wemiphunga owenzeka kwi-COPD), imeko ngokubanzi ebonwa njengengenakuguqulwa kwaye iqhubela phambili. Izigulane ezimbini ezibhalise kwilingo kunye nemeko yabonisa isisombululo sezilonda kwiiveki ze-24 nge-CT imaging.
Ivunywe yi-China yoLawulo lweeMveliso zoNyango lweSizwe (i-NMPA), elilingana ne-UK Medicines kunye ne-Healthcare Regulatory Agency (MHRA), ulingo lwezonyango lwesigaba se-II lusendleleni yokuvavanya ngakumbi ukusetyenziswa kwe-P63+ ye-progenitor cell transplantation kwindawo enkulu. iqela lezigulane zeCOPD.
Olu tshintsho lunokutshintsha ngokubonakalayo indlela yonyango kwiCOPD. Unjingalwazi u-Omar Usmani weKholeji yase-Imperial yaseLondon kunye neNtloko yeqela le-European Respiratory Society malunga nesifo somoya, isifuba, iCOPD kunye nokukhohlela okungapheliyo wanikezela ngeengcinga zakhe ngokubaluleka kovavanyo, egxininisa imfuno engxamisekileyo yonyango olusebenzayo ngakumbi lweCOPD. Waphawula ukuba ukuba ezi ziphumo ziqinisekiswa kwiimvavanyo ezilandelayo, kuya kuba yinkqubela enkulu kunyango lweCOPD.
Indlela engaphambili ibonakala ithembisa, inamandla okungapheleli nje kuphela iimpawu ezibuthathaka zeCOPD kodwa ukulungisa umonakalo ewenza kwimiphunga, inika ithemba kwizigidi zabantu abaphethwe sesi sifo singapheliyo sokuphefumla.
Unokufunda ngakumbi malunga novavanyo apha: https://www.ersnet.org/news-and-features/news/transplanting-patients-own-lung-cells-offers-hope-of-cure-for-copd/