Uphononongo olupapashwe kutshanje luchaza i-antifungals entsha esendleleni enika ithemba ngekamva.

Amachiza amatsha achazwe kuphononongo aneendlela ezintsha zokwenza ukoyisa ukunganyangeki, kwaye amanye abonelela ngemixube emitsha ebonelela ngeenzuzo ezahlukeneyo kunyango lwangoku lokuphucula iiprofayili zokhuseleko kunye nokunciphisa ukusebenzisana. Umzekelo, iRezafungin ibonise umsebenzi ngokuchasene I-Aspergillus iintlobo kwaye iye yanciphisa ubutyhefu besibindi, ukungena okungcono kunye nomngcipheko omncinci wokuxhathisa.

Kuyakhuthaza kakhulu ukubona ukuba uninzi lweekhompawundi zinentshukumo emandla ngokuchasene I-Aspergillus iintlobo kunye nokuba Ibrexafungerp, ikhompawundi echaphazela udonga lweseli lomngundo, inomsebenzi ngokuchasene eziliqela I-Aspergillus iintlobo kwaye ikwisigaba sesi-3 solingo lwezonyango.

Iingenelo ezinokubakhona kweli chiza ziquka:

• Ukuqulunqwa komlomo kunye ne-IV
• Isebenza ngokuchasene neentlobo ezixhathisayo
• Ukungena ngcono (IAC)
• Ubuncinci ukusebenzisana kweziyobisi namachiza

Ukongeza, i-olorofim, i-VL2397 kunye ne-ABA zonke zinomsebenzi onamandla ngokuchasene I-Aspergillus iintlobo kwaye zikwizigaba ezahlukeneyo zolingo lwezonyango. Lilonke, kukho ithemba lokwenene elundini phayaa