Tirada dadka khatarta ugu jira infekshinnada fangasku way sii kordhayaan sababtoo ah dadka da'da ah, isticmaalka korodhka daawooyinka difaaca jirka, xaaladaha caafimaad ee hore u jiray, isbeddellada deegaanka, iyo arrimo hab nololeed. Sidaa darteed, waxaa jirta baahi sii kordheysa oo loo qabo daaweyn cusub ama doorashooyin ka hortag ah.
Ikhtiyaarada daawaynta hadda ee caabuqa fangasku waxay inta badan ku lug leeyihiin isticmaalka dawooyinka fangas-ka-hortagga ah, sida azoles, echinocandins, iyo polyenes. Daawooyinkani guud ahaan waxay waxtar u leeyihiin daaweynta caabuqyada fangas, laakiin waxay yeelan karaan dib-u-dhacyo. Tusaale ahaan, qaar ka mid ah dawooyinka fangasku waxay la falgali karaan dawooyinka kale, taas oo u horseedaysa waxyeelooyin waxyeelo leh. Intaa waxaa dheer, isticmaalka xad-dhaafka ah ee dawooyinka antifungal waxay gacan ka geysan kartaa horumarinta caabbinta daawada fangas, taas oo ka dhigi karta daaweynta mid aad u adag.
Waxaa jirtay xiiso sii kordheysa oo laga qabo horumarinta tallaalada fangas oo ah daaweyn kale. Tallaalka fangasku wuxuu u shaqeeyaa kicinta habka difaaca si uu u soo saaro jawaab gaar ah oo ka dhan ah fungus, kaas oo bixin kara difaac waqti dheer ah oo ka hortagga caabuqa. Tallaalka waxaa la siin karaa dadka khatarta ku jira ka hor inta aan la gaarin fangaska, ka hortagga infekshanka inuu dhaco meesha ugu horeysa.
Daraasad dhowaan ay sameeyeen cilmi-baarayaal ka socda Jaamacadda Georgia ayaa muujisay suurtagalnimada tallaalka pan-fungal si looga ilaaliyo cudurada fangas ee badan, oo ay ku jiraan kuwa keena aspergillosis, candidiasis iyo pneumocystosis. Tallaalka, oo loo yaqaan NXT-2, waxaa loogu talagalay in lagu kiciyo habka difaaca si uu u aqoonsado oo uu ula dagaallamo dhowr nooc oo fangaska ah.
Daraasadu waxay ogaatay in tallaalku awood u leeyahay inuu kiciyo jawaab celin difaac adag Jiirarka iyo waxa kale oo ay ka ilaalinayaan infekshanka dhowr jeermiska fangas ee kala duwan, oo ay ku jiraan Aspergillus fumigatus, taas oo ah sababta ugu weyn ee aspergillosis. Tallaalka ayaa la ogaaday inuu yahay mid badbaado leh oo si wanaagsan loogu dulqaadan karo jiirarka, oo leh wax saameyn xun ah lama soo sheegin.
Daraasadani waxay muujinaysaa suurtagalnimada tallaalka pan-fungal si looga ilaaliyo cudur-sidaha fangas ee badan. Inkastoo cilmi-baaristu aysan si gaar ah uga hadlin isticmaalka tallaalka bukaannada qaba caabuqyada aspergillosis ee horay u jiray, natiijooyinka waxay soo jeedinayaan in tallaalku leeyahay. suurtagalnimada in laga hortago infekshanka aspergillosis ee shakhsiyaadka khatarta sare leh.
Marka la soo koobo, iyada oo horumarinta tallaallada antifungal ay bixiyaan beddelka suurtagalka ah ee suurtagalka ah ee caqabadaha ay keenayaan doorashooyinka daawaynta ee hadda jira ee caabuqyada fangas, cilmi baaris dheeraad ah ayaa loo baahan yahay si loo go'aamiyo badbaadada iyo waxtarka tallaalka ee bini'aadamka, oo ay ku jiraan kuwa qaba aspergillosis, ka hor inta aysan awoodin. loo tixgeliyo sidii doorasho daaweyn ah.
Warqad asal ah: https://academic.oup.com/pnasnexus/article/1/5/pgac248/6798391?login=false