Horumar cajiib ah oo laga sameeyay daawaynta Cudurka sambabada ee daba-dheeraada (COPD), saynis-yahannadu waxay, markii ugu horreysay, soo bandhigeen awoodda hagaajinta unugyada sambabada ee dhaawacan iyagoo isticmaalaya unugyada sambabada ee bukaanka. Horumarka ayaa lagu daah furay Shirweynaha Caalamiga ah ee Bulshada Neefsiga ee Yurub ee sanadkan ee Milan, Italy, halkaas oo natiijadii ka soo baxday tijaabada caafimaadka wajiga XNUMX la wadaagay.
COPD, oo ku badan kuwa qaba aspergillosis sambabada dabadheeraad ah (CPA), waxay sababtaa dhaawac horudhac ah oo soo gaara unugyada sambabada, taas oo si weyn u saameynaysa tayada nolosha bukaanka iyada oo loo marayo xannibaadda socodka hawada ee sambabada. Cudurka, oo galaafanaya nolosha qiyaastii 30,000 oo qof oo ku nool UK sannad kasta, ayaa taariikh ahaan caqabad ku ahaa in la daweeyo. Daawaynta hadda waxay inta badan diiradda saaraan yaraynta calaamadaha iyada oo loo marayo bronchodilators sida salbutamol, kaas oo ballaadhiyaa marinnada neef-mareenka si kor loogu qaado socodka hawada laakiin aan dayactirin nudaha dhaawacan.
Raadinta daaweyn qeexan ayaa keentay cilmi-baarayaasha si ay u sahamiyaan xaqiiqooyinka unugga tarma iyo daawada dib-u-soo-nooleynta ee unugyada hore. Unugyada stem waxay caan ku yihiin awoodda ay u leeyihiin inay u qaabeeyaan nooc kasta oo unug ah. Si ka duwan unugyada asliga ah, unugyadu waxay isu rogi karaan oo keliya noocyo unugyo gaar ah oo la xidhiidha meel gaar ah ama unug. Tusaale ahaan, unugga hore ee sambabada ayaa isu rogi kara noocyo kala duwan oo unugyo sambabada ah laakiin uma eka unugyada wadnaha ama unugyada beerka. Cilmi-baarayaasha waxaa ka mid ah Professor Wei Zuo oo ka tirsan Jaamacadda Tongji, Shanghai iyo saynisyahanka sare ee Regend Therapeutics. Professor Zuo iyo kooxdiisa Regend waxay baarayeen nooc gaar ah oo ka mid ah unugyada taranka ee loo yaqaan P63+ unugyada sambabada.
20 bukaan oo COPD ah ayaa lagu diiwaan geliyay tijaabada, 17 ka mid ah waxay heleen daaweynta unugyada, halka saddex ay u adeegeen kooxda xakamaynta. Natiijadu waxay ahayd mid dhiirigelin leh; daawaynta si wanaagsan ayaa loo dulqaatay, bukaannadu waxay soo bandhigeen shaqada sambabada oo soo hagaagtay, way sii socon karaan, waxayna soo sheegeen nolol tayo wanaagsan ka dib daawaynta.
Ka dib 12 toddobaad ee daaweyntan cusub, bukaanku waxay la kulmeen horumar la taaban karo oo ku saabsan shaqadooda sambabada. Gaar ahaan, awoodda sambabada ee ku wareejinta ogsijiinta iyo kaarboon-dioxide u gudbinta iyo ka qaadista dhiigga ayaa noqotay mid aad waxtar u leh. Intaa waxaa dheer, bukaanadu waxay sii socon karaan inta lagu jiro tijaabada socodka caadiga ah ee lix-daqiiqo ah. Dhexdhexaadka (lambarka dhexe marka dhammaan tirooyinka la habeeyo laga bilaabo kan ugu yar ilaa kan ugu weyn) fogaanta ayaa ka korodhay 410 mitir ilaa 447 mitir - calaamad wanaagsan oo ah horumarinta awoodda hawada iyo dulqaadka. Waxaa intaa dheer, waxaa jiray hoos u dhac muuqda oo ku yimid buundooyinka laga helay St George's Respiratory Questionnaire (SGRQ), oo ah qalab loo isticmaalo in lagu cabbiro saameynta cudurrada neef-mareenka ee tayada guud ee nolosha. Dhibcaha hoose waxay muujinayaan in bukaanku dareemeen in tayada noloshoodu soo hagaagtay, oo leh calaamado yar iyo shaqeyn maalinle ah oo wanaagsan. Guud ahaan, tani waxay soo jeedinaysaa in daawadu ay wanaajisay shaqada sambabada oo ay si togan u saamaysay nolosha maalinlaha ah ee bukaanka.
Natiijooyinka hordhaca ah ayaa sidoo kale iftiimiyay suurtagalnimada daaweyntan ee lagu hagaajinayo dhaawaca sambabada ee bukaanada qaba emphysema fudud (nooc ka mid ah dhaawaca sambabada ee ku dhaca COPD), xaalad guud ahaan loo arko mid aan laga noqon karin oo horumarsan. Laba bukaan oo ku diiwaangashan tijaabada xaaladdu waxay muujisay xallinta nabarrada toddobaadyada 24 ee sawirka CT.
Waxaa taageeray Maamulka Alaabada Caafimaadka Qaranka ee Shiinaha (NMPA), oo u dhiganta Hay'adda Nidaaminta Dawooyinka iyo Alaabooyinka Daryeelka Caafimaadka ee UK (MHRA), tijaabada caafimaad ee wajiga II ayaa ku jirta dhuumaha si loo sii tijaabiyo isticmaalka unugyada taranka ee P63+ si weyn kooxda bukaanada COPD.
Hal-abuurnimadani waxay si weyn u beddeli kartaa habka daaweynta ee COPD. Professor Omar Usmani oo ka tirsan Kuliyadda Imperial ee London iyo Madaxa Kooxda Neefta ee Yurub ee cudurrada marin hawo-mareenka, neefta, COPD iyo qufac daba-dheeraada ayaa bixiyay fikirradiisa ku aaddan muhiimadda tijaabada, isagoo hoosta ka xariiqay baahida degdegga ah ee daawaynta waxtarka leh ee COPD. Waxa uu xusay in haddii natiijooyinkan lagu xaqiijiyo tijaabooyinka xiga, ay noqon doonto horumar weyn oo laga gaaro daaweynta COPD.
Waddada soo socota ayaa u muuqata mid rajo leh, iyada oo ay suurtagal tahay in aan la yaraynin calaamadaha daciifka ah ee COPD laakiin in la hagaajiyo dhaawaca uu u geysto sambabada, taas oo rajo siinaysa malaayiin la ildaran cudurkan neef-mareenka.
Waxaad si faahfaahsan uga akhriyi kartaa tijaabada halkan: https://www.ersnet.org/news-and-features/news/transplanting-patients-own-lung-cells-offers-hope-of-cure-for-copd/