Tlhahiso e feteletseng ea mucus ke bothata bo tloaelehileng ho batho ba nang le Allergic Bronchopulmonary Aspergillosis (ABPAle aspergillosis e sa foleng ea matšoafo (CPA). Mucus ke motsoako o motenya oa metsi, litšila tsa lisele, letsoai, lipids le liprotheine. E etsa mela ea litsela tsa rona tsa moea, e tšoasa le ho tlosa likaroloana tse tsoang linaheng tse ling matšoafong. Botenya bo kang ba gel ba mucus bo bakoa ke lelapa la liprotheine tse bitsoang mucins. Ho batho ba nang le asthma, liphetoho tsa liphatsa tsa lefutso ho liprotheine tsena tsa mucin li ka etsa hore ho be thata ho tsoa matšoafong. Lefi le letenya le le letenya le a bokellana 'me le ka etsa hore ho be le li-mucus plugs, ho thibela moea le ho baka mathata a ho hema, ho hema, ho khohlela le matšoao a mang a ho hema.
Hangata lingaka li phekola matšoao ana ka meriana e hemang joaloka bronchodilator le corticosteroids ho bula tsela ea moea le ho fokotsa ho ruruha. Mucolytics e ka boela ea sebelisoa ho senya li-plug tsa mucus, empa meriana e fumanehang feela, N-Acetylcysteine (NAC), ha e sebetse haholo ebile e ka baka litla-morao tse sa batleheng. Le hoja liphekolo tsa morao-rao li ka thusa ho laola matšoao, ho na le tlhokahalo ea phekolo e sebetsang le e sireletsehileng ho rarolla bothata ba li-mucus plugs.
Ho rarolla bothata bona, ho ntse ho hlahlojoa mekhoa e 3:
- Mucolytics ho qhaqha li-plug tsa mucus
Bafuputsi Univesithing ea Colorado ba ntse ba leka li-mucolytics tse ncha tse kang tris (2-carboxyethyl) phosphine. Ba file mucolytic ena ho sehlopha sa litoeba tsa asthmatic tse nang le ho ruruha le tlhahiso e feteletseng ea mucus. Ka mor'a ho phekoloa, ho phalla ha mucus ho ile ha ntlafala, 'me litoeba tsa asthmatic li ne li ka tlosa mucus hantle feela joaloka litoeba tse se nang asma.
Leha ho le joalo, li-mucolytics li sebetsa ka ho khaola maqhama a tšoarang li-mucins hammoho, 'me litlamo tsena li fumanoa liprotheine tse ling' meleng. Haeba litlamo li robehile liprotheine tsena, li ka lebisa litla-morao tse sa batleheng. Ka hona, lipatlisiso tse ling lia hlokahala ho fumana sethethefatsi se tla lebisa feela litlamo tsa mucins, ho fokotsa kotsi ea litla-morao.
2. Ho hloekisa likristale
Ka mokhoa o mong, Helen Aegerter le sehlopha sa hae Univesithing ea Belgium ba ntse ba ithuta ka likristale tsa protheine tseo ba lumelang hore li susumetsa tlhahiso e feteletseng ea mucus ho asthma. Likristale tsena, tse tsejoang ka hore ke Charcot-Leyden crystals (CLC's) li etsa hore mucus e be motenya, ka hona ho thata ho hlakola moeeng.
E le ho sebetsana le likristale ka ho toba, sehlopha se ile sa hlahisa li-antibodies tse hlaselang liprotheine tse ka har'a likristale. Ba ile ba etsa liteko tsa li-antibodies ho lisampole tsa mucus tse bokelletsoeng ho batho ba nang le asthma. Ba fumane hore li-antibodies li ile tsa qhala likristale ka nepo ka ho ikamahanya le libaka tse ikhethileng tsa liprotheine tsa CLC tse li kopanyang. Ho feta moo, li-antibodies li fokolisa ts'ebetso ea ho ruruha ho litoeba. Ho latela liphuputso tsena, joale bafuputsi ba ntse ba sebetsa ka sethethefatsi se ka bang le phello e tšoanang ho batho. Aegerter o lumela hore mokhoa ona o ka sebelisoa ho phekola maloetse a sa tšoaneng a ho ruruha a kenyelletsang tlhahiso e feteletseng ea mucus, ho akarelletsa le ho ruruha ha sinus le mekhoa e itseng ea ho kula ho likokoana-hloko tsa fungal (tse kang ABPA).
- Ho thibela secretion e feteletseng ea mucus
Ka mokhoa oa boraro, setsebi sa matšoafo Burton Dickey sa Univesithi ea Texas se sebetsa ho thibela li-mucus plugs ka ho fokotsa tlhahiso e feteletseng ea mucus. Sehlopha sa Dickey se ile sa tsebahatsa mofuta o itseng oa lefutso, Syt2, o amehang feela tlhahisong e feteletseng ea mucus eseng tlhahisong e tloaelehileng ea mucus. Ho thibela tlhahiso e feteletseng ea mucus, ba ile ba etsa moriana o bitsoang PEN-SP9-Cy o thibelang ketso ea Syt2. Mokhoa ona oa ts'episa haholo kaha o shebane le tlhahiso e feteletseng ea mucus ntle le ho kena-kenana le mesebetsi ea bohlokoa ea mucus e tloaelehileng. Tlhahiso e tloaelehileng ea mucus e phetha karolo ea bohlokoa ho sireletseng le ho boloka bophelo bo botle ba tsamaiso ea ho hema le ea tšilo ea lijo. Leha liphetho tsa pele li ts'episa, lipatlisiso tse ling lia hlokahala ho lekola katleho le polokeho ea lithethefatsi tsena litekong tsa bongaka.
Ka kakaretso, li-plug tsa mucus li hlahisa matšoao a sa phutholohang ho ABPA, CPA le asthma. Liphekolo tsa morao-rao li shebana le taolo ea matšoao ho e-na le ho bua ka ho toba ho fokotsa kapa ho tlosa li-plug tsa mucus. Leha ho le joalo, bafuputsi ba ntse ba hlahloba mekhoa ea 3 e ka 'nang ea e-ba teng, e kenyelletsang mucolytics, ho hloekisa likristale, le ho thibela secretion e feteletseng ea mucus. Lipatlisiso tse ling lia hlokahala ho netefatsa katleho ea tsona le polokeho, empa mekhoa e bonts'itse liphetho tse ts'episang mme e kanna ea ba tsela e 'ngoe eo re ka thibelang li-mucus plug nakong e tlang.
Lintlha tse ling hape: