I-Aspergillosis Isiguli Nokusekelwa

Kuhlinzekwe yi-NHS National Aspergillosis Center

I-Biologics kanye ne-eosinophilic asthma

Iyini i-eosinophilic asthma?

I-Eosinophilic asthma (EA) yisifo esinzima esibandakanya uhlobo lwengqamuzana elimhlophe legazi elibizwa ngokuthi ama-eosinophils. Lamangqamuzana omzimba omzimba asebenza ngokukhipha amakhemikhali anobuthi abulala amagciwane ayingozi. Ngesikhathi sokutheleleka, baphinde basize ukugqugquzela ukuvuvukala okuvumela ukuthi amanye amangqamuzana omzimba ahanjiswe endaweni ukuze alungise. Kodwa-ke, kubantu abane-EA la ma-eosinophil aba ngokungalawuleki futhi abangele ukuvuvukala okudlulele kwemigudu yokuphefumula kanye nesistimu yokuphefumula, okuholela ezimpawu ze-asthmatic. Ngakho-ke, ekwelashweni kwe-EA, inhloso ukunciphisa amazinga e-eosinophil emzimbeni.

Thola okwengeziwe nge-EA lapha - https://www.healthline.com/health/eosinophilic-asthma

I-Biologics

I-Biologics iwuhlobo olukhethekile lwemithi (amasosha omzimba e-monoclonal) enikezwa ngomjovo kuphela futhi okwamanje asathuthukiswa ukwelapha izifo ezihlukahlukene lapho amasosha omzimba ethu edlala indima, isib. isifuba somoya kanye nomdlavuza. Akhiqizwa ezintweni eziphilayo zemvelo ezinjengabantu, izilwane kanye nama-microorganisms futhi afaka uchungechunge lwemikhiqizo efana nemithi yokugoma, igazi, izicubu kanye nokwelashwa kwamaseli ofuzo.

Okuningi ngama-antibodies e-monoclonal - https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/monoclonal-antibodies.html

Okuningi nge-biologics - https://www.bioanalysis-zone.com/biologics-definition-applications/

Ziqondiswe kakhulu kunezinye zokwelapha isifuba somoya njenge-steroids ngoba zihloswe engxenyeni ethile ethile yamasosha omzimba, zinciphisa imiphumela emibi. I-Biologics ithathwa ngokuhambisana ne-steroids, kodwa umthamo we-steroid odingekayo wehliswa kakhulu (ngenxa yalokho imiphumela emibi eyenziwa yi-steroid nayo iyancishiswa).

Kukhona okwamanje Izinhlobo ezi-5 zebhayoloji etholakalayo. Lezi izi:

  • I-Reslizumab
  • I-Mepolizumab
  • Benralizumab
  • Omalizumab
  • I-Dupilumab

Amabili okuqala kulolu hlu (reslizumab ne-mepolizumab) asebenza ngendlela efanayo. Baqondise ingqamuzana eyenza ama-eosinophil asebenze; leli ngqamuzana liyiphrotheni elincane elibizwa nge-interleukin-5 (IL-5). Uma i-IL-5 iyeka ukusebenza, khona-ke ukusebenza kwe-eosinophil nakho kuvinjelwe futhi ukuvuvukala kunciphisa.

I-Benralizumab iphinde iqondise ama-eosinophil kodwa ngendlela ehlukile. Ibophezela kuwo okuheha amanye amangqamuzana abulala amasosha omzimba egazini ukuthi eze azobhubhisa i-eosinophil. Le ndlela yezidakamizwa yehlisa/iqeda kakhulu ama-eosinophil uma iqhathaniswa ne-reslizumab ne-mepolizumab.

I-Omalizumab iqondise i-antibody ebizwa nge-IgE. I-IgE ivuselela ukusebenza kwamanye amangqamuzana avuthayo ukuze akhulule amakhemikhali afana ne-histamine njengengxenye yokusabela kokungezwani komzimba. Le mpendulo ibangela ukuvuvukala ngaphakathi kwemigudu yomoya futhi ibangele izimpawu zesifuba somoya. I-allergies aspergillus ingaqala le ndlela, okusho ukuthi iziguli ezine-ABPA zivame ukuba ne-EA. I-Omalizumab ingavimba lokhu kusabela kokungezwani komzimba futhi ngaleyo ndlela inciphise izimpawu ze-asthmatic ezilandelayo.

I-biologic yokugcina, i-dupilumab, nayo inconywa kubantu abane-asthma enzima ehambisana nokungezwani komzimba. Isebenza ngokuvimbela ukukhiqizwa kwamaprotheni amabili abizwa ngokuthi i-IL-13 ne-IL-4. Lawa maprotheni adala impendulo yokuvuvukala okuholela ekukhiqizweni kwamafinyila kanye nokukhiqizwa kwe-IgE. Futhi, uma la maprotheni amabili evinjiwe, ukuvuvukala kuzokwehla.

Ukuze uthole ukwaziswa okwengeziwe ngale mithi, vakashela iwebhusayithi ye-asthma UK -  https://www.asthma.org.uk/advice/severe-asthma/treating-severe-asthma/biologic-therapies/

Tezepelumab

Okubi kakhulu, kukhona umuthi omusha we-biologic emakethe obizwa nge-Tezepelumab. Lo muthi usebenza phezulu kakhulu endleleni yokuvuvukala ngokukhomba i-molecule ebizwa nge-TSLP. I-TSLP ibalulekile ezicini eziningi zempendulo yokuvuvukala futhi inemiphumela eminingi eminingi. Lokhu kusho ukuthi konke okuhlosiwe (okungezwani nomzimba kanye ne-eosinophilic) kwe-biologics etholakalayo njengamanje kufakwe kulo muthi owodwa. Ocwaningweni lwakamuva olwenziwa ngaphezu konyaka owodwa, i-Tezepelumab (ihlanganiswe ne-corticosteroids) izuze ukuncipha okungama-56% kwezinga lokubhebhetheka kwesifuba somoya. Lo muthi uzovunywa yi-FDA ngekota yokuqala ka-2022. Uma usuvunyiwe, uzofinyeleleka njengengxenye yokuhlolwa komtholampilo noma ngezimali zecala ngalinye ezivela emaqenjini e-clinical commissioning, kodwa-ke ngeke utholakale. ku-NHS ize ivunyelwe yi-NICE. Noma kunjalo, i-Tezepelumab inikeza ithemba emkhathizwe kubantu abahlushwa yi-EA.

I-NICE imihlahlandlela

Ngeshwa, akuyona yonke le mithi efinyeleleka kalula e-UK futhi ukuze inqunywe isiguli kufanele sihlangabezane nemibandela eqinile evela ku-National Institute for Health and Care Excellence (NICE). Ukuze unikezwe i-biologics, kufanele ubambelele ohlelweni lwakho lokwelapha lwamanje futhi uphuze imithi yakho ngendlela efanele. Lawa ma-biologics atholakala emitholampilo yochwepheshe efana ne-North West Lung Centre esesibhedlela i-Wythenshawe, e-Manchester ehlola isiguli bese ifaka isicelo semali yokuqaliswa komuthi uma kufanelekile.

Sicela ubheke imihlahlandlela ye-NICE yezidakamizwa ezitholakala ngezansi njengamanje:

Uma ngabe uthatha imishanguzo ye-steroid engasebenzi futhi unomuzwa wokuthi ungazuza kule mithi, khuluma nomeluleki wakho wokuphefumula.