Vitamin D deficiency may increase amphotericin B-related kidney toxicity

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Graph showing that mice with vitamin D deficiency had more kidney toxicity from amphotericin B

Do you take vitamin D supplements over winter?

Current NHS/PHE guidelines say that all adults should consider taking vitamin D supplements between October and March, or all year round if they are at risk of deficiency (e.g. people who have darker skin, or spend most of their time indoors or covered up).

But a new study suggests it might be even more important for people living with aspergillosis. Ferreira et al 2019 found that mice with a vitamin D deficiency experienced more kidney toxicity when given amphotericin B (lipid formulation). Click here to read more here.

If you haven’t had your levels tested recently, it might be worth getting your doctor to check them.

When taking vitamin D supplements:

  •  For best absorption, take it with a meal containing fat and calcium
  •  Check the label for the dosage – it should be 10-25 mcg per day, or 400-1000 IU (don’t rely on % RDA/NRV)
  •  There are two forms: D3 (cholecalciferol) is more effective than D2 (ergocalciferol)

For more information on Vitamin D guidelines:

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