Kudzidzisa immune system kuziva & kubatsira kubvisa invasive aspergillosis

Kurapa aspergillosis, munyaya iyi, acute invasive aspergillosis, nemishonga inorwisa fungal ine painogumira. Anowanzoita muchetura uye anofanirwa kushandiswa nemazvo nevarapi vane ruzivo. Pakurapa munhu ane immunocompromised zvakanyanya ane utachiona Aspergillus (iro ndiro boka guru revanhu vanowana acute invasive fomu yechirwere ichi) huwandu hwevanhu vanofa hunogona kudarika 50% mumapoka evarwere vari kurapwa leukemia. Zviri nyore kuona kuti tinoda kugadzira marapiro ari nani uye nzira dzakasiyana dzekurapa.

Anti-Afumigatus mab inoziva A. fumigatus hyphae

Anti-Afumigatus mab inoziva A. fumigatus hyphae

Boka rekuGerman rekutsvagisa paYunivhesiti yeWurtzburg, rinotungamirwa naJurgan Loffler naMichael Hudacek vakatora nzira yakasiyana zvachose yekurapa aspergillosis, panzvimbo yekugadzira mishonga inorwisa fungal vakasarudza 'kudzidzisa' immune system yevarwere vasina kudzivirirwa kuti vazive uye kurwisa utachiona huri nani netariro yekuti izvi zvichavandudza kufa.

Iyi tekinoroji yakakopwa kubva mukutsvagisa cancer, kwatinoziva kuti mamwe magomarara anotiza kurwiswa kubva kune immune system uye izvi zvinoita kuti gomarara rikure. Vatsvakurudzi vari zvinobudirira 'kudzidzisazve' immune system yemugamuchiri kurwisa masero egomarara zvakanyanya.

Boka racho rakatora maseru kubva mukudzivirira kwembeva (T-cells) anowanzo kurwisa kutapurira hutachiona kuitira kubvisa hutachiona uye kuwedzera kugona kwavo kuwana. Aspergillus fumigatus, inova ndiyo hombe pathogen inokonzera aspergillosis. Macell aya akabva apihwa mbeva dzakabatwa nadzo Aspergillus mbeva modhi system yakagadzirirwa kutevedzera acute invasive aspergillosis muvarwere vevanhu.

Mhedzisiro yaive yekuti yemakonzo akange aine invasive pulmonary aspergillosis uye asina kurapwa, 33% yakaramba iri mupenyu nepo kune iwo mbeva dzairapwa ne booster T-cells (CAR-T) 80% vakapona.

Ichi chigumisiro chinoratidza vimbiso yakawanda yekurapa aspergillosis. Iyi mibairo yekuedza inoda kudzokororwa mumunhu anogamuchira asi zviri pachena kuti nzira iyi inogona kuumba hwaro hwenzira nyowani yekurapa aspergillosis, kusanganisira isingaperi mafomu easpergillosis akadai senge chronic pulmonary aspergillosis (CPA) uye pamwe kunyange allergic bronchopulmonary. aspergillosis (ABPA).

Bepa rakazara rakabudiswa pano

Yakagadziridzwa Kuwedzeredzwa munaGunyana 29, 2022 na arun