Kurwara
Kwenguva yakareba kwazvo, sayenzi yezvokurapa yakafungidzira kuti zvirwere zvinotapukira zvinokonzerwa nekuvapo kwechirwere uye kushaya simba mumunhu ane utachiona kana mubati sezvaanowanzozivikanwa, izvo zvinoita kuti pathogen ikure uye iparadze. Hutera hwacho hunogona kunge huri semuenzaniso kudzikira immune system kunokonzerwa nechirwere chemajini kana immune-suppressive kurapwa sekushandiswa kwevanotapurirana varwere.
Taifungidzira kuti mukati memiviri yedu maigara muine nharaunda isina utachiona, uye chikonzero chimwe chatingazorwara chingava utachiona hunopinda mune imwe yenzvimbo dzisina utachiona uye hwobva hwakura zvisingadzoreki. Imwe yenzvimbo dzisina utachiona yaive mapapu edu - saka makore makumi matatu kusvika makumi mana apfuura vazhinji vangadai vakagumisa kuti aspergillosis yakakonzerwa ne Aspergillus spore ichipinda mumapapu emugamuchiri uye yobva yakwanisa kukura.
microbiome
Munenge mugore ra2000 takatanga kukwanisa kutarisa nzvimbo dzedu dzomukati zvakadzama uye kuziva chero hutachiona hunogona kunge huripo, Zvakawanikwa zvakashamisa, somuenzaniso, taigona kuwana utachiona hwakawanda; mabhakitiriya, fungi uye utachiona 'kukura mumapapu edu pasina kukonzera chero zviratidzo zvinokuvadza. Zvakajairika kuwana Aspergillus fumigatus (kureva utachiona hwatinofungidzira kuti hunokonzera aspergillosis kazhinji) huri mumapapu evazhinji vedu kwahunogara pasina kukonzera aspergillosis. Izvo zvinogoneka sei uye ndeupi mutsauko uripo pakati peiyo mamiriro uye allergy & kutapukira kunokonzerwa mumapapu easpergillosis murwere?
Takakurumidza kuziva kuti utachiona hwaigona kutanga nzanga dzisingakuvadzi, dzichigara mutsinhirano nomumwe nomumwe uye negadziriro yedu yokudzivirira zvirwere. Nharaunda iyi yakanzi munhu microbiome uye yaisanganisira utachiona hwese hunogara mukati medu uye patiri. Huwandu hukuru hunogara mumatumbo edu, kunyanya muura hwedu hombe inova chikamu chekupedzisira chekudya kwedu kugamuchira chikafu chisati chaburitswa kuburikidza nerectum.
Shamwari dzedu dzeMicrobial
Zvakabva zvabuda kuti A. fumigatus inogona kudzorwa nevavakidzani vayo vane hutachiona (microbiome yedu) ichishanda mukubatana kwakanyatso kudzora ne immune system yedu.
Iyo fungal pathogen inodyidzana nemugamuchiri kudzikamisa mhinduro yemugamuchiri kune pathogen uye inoshandisa zvikamu zve immune system yemuridzi kuita izvi. Nenzira iyi mugadziri uye hutachiona hunoshivirirana uye kuita kukuvadza kushoma, zvisinei, zvakaratidzwa kuti kana zvikamu zveiyo fungal recognition system isiri kushanda ipapo mugadziri anotanga mhinduro yehasha yekuzvimba. Izvi hazvina kusiyana nemamiriro ezvinhu muABPA apo imwe yematambudziko makuru ndeye tambira zvakanyanya-kupindura kune fungus.
Isu tinopihwawo muenzaniso weiyo microbiome inodzora iyo host immune mhinduro kune fungal pathogen. Kupokana nehutachiona kunogona kuwedzerwa nehuwandu hwehutachiona huri mumatumbo hunonzwa chiratidzo - zvichida muchikafu chinopinzwa nemugamuchiri. Izvi zvinoreva kuti zvakatipoteredza zvinogona kukanganisa kurambwa kwepathogen nevavakidzani vayo vane hutachiona - meseji yatingatore kubva pane iyi kutarisa. mushure medu gut microbiome, uye ichatichengeta. Izvi zvinobatawo hutachiona mumapapu edu, kwatakaona mutsauko mumhando nenzvimbo dzebhakitiriya mumigwagwa yekumusoro neyepasi inoita seinoenderana neiyo microbiome inodzora kuzvimba - vanyori vanofungidzira kuti isu tinofanirwa kutarisa zvinoitika. patinodenha aya mapapu microbiotas ane hutachiona hwehutachiona hwakanyanya senge Aspergillus fumigatus.
Iyo microbiome zvakare inozvidzora yega chero ichichengetwa ine hutano. Utachiona hunogona kurwisa fungi, fungi inogona kurwisa mabhakitiriya muhondo inoenderera mberi yekudya. Hosha dzehutachiona dzinogona kubviswa zvachose kubva kune microbiome nemamwe hutachiona.
Ma microbiome akasiyana mune imwe chikamu chemuviri wedu anogona kupindirana uye kutonga zvirwere zvakaita seasthma (kureva. lung microbiome inodyidzana negut microbiome) - saka izvo zvaunodya zvinogona kukanganisa hutachiona mugut microbiome yako uye izvo zvinogona kukanganisa asima yako, semuyenzaniso.
Ndinofanira kukuyambira kuti zvakawanda zvakacherechedzwa zvataurwa pamusoro apa zvakavakirwa pazviyedzo zvishoma kusvika pari zvino, uye zvakanyanya pamasisitimu emhando yemhuka uye. Candida pane ku Aspergillus saka tinofanira kungwarira mukududzira kwedu maererano ne aspergillosis, zvisinei kune mashoma ekuenda kumba meseji anofanirwa kurangarirwa.
- Vanhu vazhinji vane hutano vanoratidzika kunge vane hutano hwakanyanya, hwakasiyana-siyana microbiomes - saka chengetedza yako nekudya kwakadzikama kune zvakawanda zvezvirimwa, fiber yakawanda.
- Vatsvagiri vanoita kunge vari kushandura fungidziro yedu yekuti hutachiona ndeupi mumusoro - vanoita kunge vari kuti kuzvimba kunokonzera kutapukira, kwete kutapukirwa kunokonzera kuzvimba.
- Zvaunodya zvinogona kuita zvakananga pahuwandu hwekuzvimba hunoshandiswa nemuviri wako mukupindura kune zvaunoona sepathogen.
Hazvigone kuve kuti zvirwere zvakaita seasthma neABPA zvinokonzerwa neiyo isina hutano microbiome ingadaro?
Tsvagiridzo yemazuva ano inoratidzika kunge iri kuratidza kuti inogona kuita chikamu, saka kukosha kweumwe munhu ane aspergillosis kuita zvavanogona kusimudzira nharaunda ine hutano yehutachiona mukati mavo haigone kuwedzeredzwa.