SAFS - Yakanyanya asima ine fungal sensitization

Iwe une asthma inogara ichikwira zvichikonzera kushanya kuchipatara here?
Kana iwe ukaongororwa uye ukawanikwa uine hanya nefungi unogona kunge uine SAFS.

Chiremba wako angave asina kunzwa nezvechirwere ichi kana kuti angave asina chokwadi chekuti chiriko. Izvi zvakajairika kune ichangobva kutaurwa chikonzero chehurwere, uye nguva chete ichaita kuti munhu wese avepo. Yave iri nyaya yemakiriniki akati wandei akapofumadzwa kaviri uye saka humbowo huri kuwedzera. Dhinda peji rino uye riratidze kuna chiremba wako kana uine hanya kuti ungave uine SAFS.

Varwere vane SAFS vane asthma inonetsa. Ivo varume vakuru kana vanhukadzi, vane zera repakati pakuongororwa kwe ~ 50 makore. Basa ravo repulmonary rakayerwa neFEV1 kana kuyerera kwepamusoro kunosiyana kubva pa20-120% yakafanotaurwa, zvichienderana nekuti chirwere chavo chinodzorwa sei.

mufananidzo wemunhu anoshandisa inhaler - mamiriro evanhu vane asthma yakaoma nefungal sensitization (SAFS) inogona kukwidziridzwa nekufema fungal spores.

mupiro

Vazhinji vane akakosha mhuno zviratidzo zvine runny mhuno, kuhotsira uye hayfever-senge zviratidzo. Izvo hazviburitse mapulagi echikosoro, sezvinoita varwere veABPA, kunyangwe CT scans inogona kuratidza imwe mucous mumhepo. Eosinophilia inowanzoitika. Vazhinji vanotsamira chose pamushonga wakanyanya inhaled corticosteroids, neinopindirana makosi emuromo steroid inodiwa kuti iwedzere, uye mamwe pane inoenderera oral steroids. Zvisingaperi zvinoramba zvichiitika zviratidzo zveasthma izvo zvisingadzoreki zvakanaka nemishonga yakawanda chinhu chakajairika cheSAFS. Kupinzwa muchipatara nekuda kwekuwedzerwa kweasthma kwakajairika.

Maitiro ekutsanangura SAFS ndeaya:

Nepo vamwe varwere vachinzwisiswa kune akawanda fungi, ruzhinji runongoita kune imwe yemafungi maviri. Mafungiro anonyanya kuzivikanwa ayo varwere vanokurudzirwa kuti: A. fumigatus uye C. albicans, ne A. alternata, Trichopyton sp., Cladosporium herbarum, Penicillium chrysogenum uye Botrytis cinerea. Mibairo yekuongorora ganda kazhinji haienderane nemhedzisiro yeRAST. RAST titres (ku A. fumigatus) akadzikira zvakanyanya kupfuura titres muvarwere vane ABPA.

mabatiro

Varwere vane SAFS vanowanzo shandisa mishonga yakawanda. Yenguva refu yekufemerwa uye kazhinji kosi yeoral corticosteroids inowanzo kudzora varwere zvakanyanya zviratidzo, asi vane zvinonyatsozivikanwa zviitiko zvakaipa. Varwere ava vanowanzotora kwenguva pfupi kana kwenguva refu-beta-2 agonists, kana leukotriene vanopikisa vane humwe rubatsiro.

Antifungal therapy pamwe itraconazole (200mg nemuromo, kaviri pazuva) inobatsira pakuva nemhedzisiro yakakura pazviratidzo zvemapapu uye nemhino. (Kurapa kwemishonga yekuongorora inorayirwa kuti itraconazole iwedzere kuratidzwa kune itraconazole, izvo zvingada kuchinja pakati pe capsules nemuromo mhinduro, uye dzimwe nguva kusimudza kana kuderedza dose). Fluconazole inogona kubatsira kune avo vanonzwa trichophyton spp. Nguva inodiwa yekurapa antifungal haina chokwadi.

Kuti uwane rumwe ruzivo nezve marudzi e aspergillosis uye zviratidzo zvavo uye kurapwa shanyira zvinotevera zvinongedzo:

Yakagadziridzwa Kuwedzeredzwa muna Zvita 14, 2019 na Megan