Biologics uye eosinophilic asima

Chii chinonzi eosinophilic asthma?

Eosinophilic asthma (EA) chirwere chakakomba chinosanganisira rudzi rwemasero machena eropa anonzi eosinophils. Aya masero ekudzivirira muviri anoshanda nekuburitsa makemikari ane chepfu anouraya utachiona hunokuvadza. Munguva yehutachiona, ivo vanobatsirawo kukurudzira kuzvimba izvo zvinoita kuti mamwe maseru ekudzivirira aendeswe kunzvimbo kuti agadzirise. Zvisinei, muvanhu vane EA idzi eosinophils dzinova dzisina kurongeka uye dzinokonzera kuwedzera kwekuputika kwemhepo uye kufema, zvichiita kuti zviratidzo zveasthmatic. Naizvozvo, mukurapa kweEA, chinangwa ndechekudzikisa mazinga eosinophils mumuviri.

Tsvaga zvimwe nezve EA pano - https://www.healthline.com/health/eosinophilic-asthma

Biologics

Biologics imhando yemishonga ine mazvikokota (monoclonal antibodies) inopihwa nejekiseni chete uye parizvino iri kugadzirwa kurapa zvirwere zvakasiyana apo masoja emumuviri wedu anoita chikamu semuenzaniso asima negomarara. Izvo zvinogadzirwa kubva kuzvisikwa zvipenyu zvakaita sevanhu, mhuka uye tupukanana uye zvinosanganisira huwandu hwezvigadzirwa zvakaita sejekiseni, ropa, matishu uye gene cell kurapwa.

Zvimwe pane monoclonal antibodies - https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/monoclonal-antibodies.html

Zvimwe pane biologics - https://www.bioanalysis-zone.com/biologics-definition-applications/

Ivo vanonangwa zvakanyanya kupfuura mamwe marapirwo easthma senge steroids nekuti anonangwa pane imwe chaiyo chikamu che immune system, kuderedza mhedzisiro. Biologics inotorwa pamwe chete ne steroids, asi chiyero che steroid chinodiwa chakaderedzwa zvakanyanya (nekudaro steroid-induced side effects inoderedzwawo).

Ikozvino kune 5 marudzi ebiologics aripo. Izvi ndezvi:

  • Reslizumab
  • Mepolizumab
  • Benralizumab
  • Omalizumab
  • Dupilumab

Iwo maviri ekutanga pane iyi runyorwa (reslizumab uye mepolizumab) anoshanda nenzira yakafanana. Vanotarisa sero rinoita eosinophils; sero iri ipuroteni diki inonzi interleukin-5 (IL-5). Kana IL-5 ikamiswa kushanda, ipapo eosinophil activation inodziviswawo uye kuzvimba kunoderedza.

Benralizumab zvakare inotarisa eosinophils asi neimwe nzira. Inosunga kune iyo inokwezva mamwe masero emuropa anouraya emuropa kuti auye kuzoparadza eosinophil. Iyi nzira yemishonga inonyanya kuderedza / kubvisa eosinophils kana ichienzaniswa ne reslizumab uye mepolizumab.

Omalizumab inonangisa antibody inonzi IgE. IgE inokurudzira kushandiswa kwemamwe masero anopisa kuti asunungure makemikari akadai sehistamine sechikamu chemhinduro yeallergic. Iyi mhinduro inoguma nekuzvimba mukati memhepo uye inokonzeresa zviratidzo zveasthmatic. An allergy to aspergillus inogona kumisa nzira iyi, zvichireva kuti varwere vane ABPA vanowanzove neEA. Omalizumab inogona kuvharisa iyi allergic mhinduro uye nekudaro kuderedza zvinotevera zviratidzo zveasthmatic.

Iyo yekupedzisira biologic, dupilumab, yatove iripo muScotland asi gore rapfuura yakabvumidzwa neNICE (ona pazasi) kuti ishandiswe muUK yese uye ichave inowanikwa mukutanga kwa2022. Kufanana ne omalizumab, inokurudzirwa zvakare kune vanhu vane asthma yakaoma. zvakabatana ne allergy. Inoshanda nekuvhara kugadzirwa kwemapuroteni maviri anonzi IL-13 uye IL-4. Aya mapuroteni anotanga mhinduro yekuzvimba iyo inotungamira mukugadzirwa kwemucus uye kugadzirwa kweIgE. Zvakare, kana mapuroteni maviri aya avharwa, kuzvimba kunoderera.

Kuti uwane rumwe ruzivo nezvemishonga iyi, shanyira asthma UK webhusaiti -  https://www.asthma.org.uk/advice/severe-asthma/treating-severe-asthma/biologic-therapies/

Tezepelumab

Nehurombo, kune mutsva biologic mushonga pamusika unonzi Tezepelumab. Mushonga uyu unoshanda zvakanyanya kumusoro munzira yekuzvimba nekunangana nemorekuru rinonzi TSLP. TSLP yakakosha mune zvakawanda zvemhinduro yekuzvimba uye ine huwandu hwakawanda hwemhedzisiro. Izvi zvinoreva kuti zvese zvinonangwa (allergic uye eosinophilic) zveiyo iripo biologics zviripo zvakafukidzwa mumushonga mumwe chete uyu. Mukuedzwa kwechangobva kuitwa kwakaitwa kwegore rimwe chete, Tezepelumab (pamwe chete necorticosteroids) yakawana kuderedzwa kwe56% muhuwandu hwekuwedzera kweasthma. Mushonga uyu uri kutenderwa neFDA muchikamu chekutanga cha2022. Kana wangotenderwa, unokwanisa kusvikirika sechikamu chemiedzo yekiriniki kana kuburikidza nenyaya-ne-case mari kubva kumapoka ekumisikidza emakiriniki, zvisinei haizovepo. paNHS kusvika yatenderwa neNICE. Zvakangodaro, Tezepelumab inopa tariro pakatarisana nevanhu vanotambura neEA.

NICE nhungamiro

Nehurombo, haisi yese yemishonga iyi inowanikwa nyore muUK uye kuti inyorerwe murwere anofanirwa kusangana nemaitiro akasimba kubva kuNational Institute for Health and Care Excellence (NICE). Kuti upiwe biologics, unofanirwa kunge uchitevedzera chirongwa chako chekurapa uye kutora mishonga yako nemazvo. Aya mabiologics anowanikwa kubva kumakiriniki ehunyanzvi akadai seNorth West Lung Center muWythenshawe Hospital, Manchester vanoongorora murwere vonyorera kuti vawane mari yekuti mushonga uyu utange kana vachikodzera.

Ndokumbira utarise kune NICE nhungamiro yemishonga iripo pazasi:

Kana wanga uchitora steroid kurapwa isingashande uye unonzwa kuti unogona kubatsirwa nemishonga iyi, taura nemubatsiri wako wekufema.

 

 

Yakagadziridzwa Kuwedzeredzwa muna Zvita 7, 2021 na Katy McGuinness